Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one derivatives containing benzo[d][1,2,3]thiadiazole against Meloidogyne incognita
Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one derivatives containing benzo[d][1,2,3]thiadiazole against Meloidogyne incognita
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苯并[d][1,2,3]噻二唑1,2,3-苯并三嗪-4-酮衍生物的合成及其对南方根结线虫的杀线虫活性
DOI：
10.1016/j.bmcl.2020.127369
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发表时间：
2020
影响因子：
2.7
通讯作者：
Xu Xiaoyong
中科院分区：
文献类型：
--
作者：
Zhang Ruifeng;Guo Wei;Wang Gaolei;Chen Xiulei;Li Zhong;Xu Xiaoyong
根据苯并[d][1,2,3]噻二唑诱导植物获得性全身性抗性和提高植物免疫力的特点，将苯并[d][1,2,3]噻二唑引入1,2,3-苯并三嗪-4- 1,31个含苯并[d][1,2,3]噻二唑的新型1,2,3-苯并三嗪-4- 1衍生物中设计合成。杀线虫活性表明，大多数合成的化合物在体内对20 mg/L的隐丝虫病有较强的抑制活性。在31个被试化合物中，a2和a3在浓度为1.0 mg/L时表现出良好的杀线虫活性，抑制率分别为50.4%和53.1%。研究了取代基类型和位置对反应的影响。并初步分析了结构与活性的关系。
Based on the characteristic of benzo[d][1,2,3]thiadiazole to induce the systemic acquired resistance and improve the immunity of plants, benzo[d][1,2,3]thiadiazole was introduced into 1,2,3-benzotriazin-4-one, thirty-one novel 1,2,3-benzotriazin-4-one derivatives containing benzo[d][1,2,3]thiadiazole were designed and synthesized. Nematicidal activity showed that most of the synthesized compounds exhibited great inhibitory activityin vivoagainst Meloidogyne incognita at 20 mg/L. Among 31 tested compounds,A2andA3showed an excellent nematicidal activity with the inhibition rate of 50.4% and 53.1% at the concentration of 1.0 mg/L, respectively. The influence of substituent type and position was investigated. The relationship between structure and activity was also preliminary analyzed.