Brain lesion in a Wistar rat. Encephalitozoonosis.
Brain lesion in a Wistar rat. Encephalitozoonosis.
复制标题
Wistar 大鼠的脑损伤。
DOI：
10.1038/laban0908-401
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发表时间：
2008
期刊：
影响因子：
6.9
通讯作者：
Wells,MoniqueY
中科院分区：
文献类型：
--
作者：
Murkunde,YogeshkumarV;Kalaiselvan,Ponnusamy;Vijayakumar,Subramaniyan;Hemalatha,Kuppusamy;Maronpot,RobertR;Herbert,RonaldA;Wells,MoniqueY
在对一种农用化合物进行的为期两年的致癌研究中，组织病理学评估显示，一只雌性Wistar大鼠的大脑出现坏死和中度炎症。Wistar/NIN大鼠160只，雌雄各230只，随机分为4组，每组5只，饲养在标准饲养条件下(室温18-21℃，相对湿度40-70%，光照：暗周期12小时：12小时)，笼内装有不锈钢烤架盖。他们得到了小而圆的饲料块(通过将测试物质与来自印度浦那的Amrut实验室动物饲料公司的粉状饲料混合而成)，以及自由过滤的紫外线处理水。测试物质的剂量分别为0，10,000，20,000和40,000 ppm，为期两年。大鼠来自国际生物技术和毒理学研究所(泰米尔纳德邦，印度)繁育群体。
During a two-year carcinogenicity study on an agrochemical compound, histopathological evaluation showed necrosis and moderate inflammation in the brain of a female Wistar rat. The study was performed under Good Laboratory Practice (GLP) guidelines.Four hundred and sixty Wistar/NIN rats (230 males and 230 females) were divided into four groups and housed five per cage in polypropylene cages with stainless steel grill lids under standard husbandry conditions (room temperature 18–21 C, relative humidity 40–70%, light: dark cycle of 12 h: 12 h). They received small, round masses of feed (prepared by mixing the test substance with powdered diet from Amrut Laboratory Animal Feed, Pune, India) and filtered, ultraviolet-treated water ad libitum. The test substance was administered at doses of 0, 10,000, 20,000 and 40,000 ppm over a 2-year period. Rats were obtained from the International Institute of Biotechnology and Toxicology (Tamil Nadu, India) breeding colony.