Strategies Used by Bacteria to Grow in Macrophages.
Strategies Used by Bacteria to Grow in Macrophages.
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DOI：
10.1128/microbiolspec.mchd-0012-2015
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发表时间：
2016-06
影响因子：
3.7
通讯作者：
Portnoy DA
中科院分区：
文献类型：
--
作者：
Mitchell G;Chen C;Portnoy DA
细胞内细菌病原体引起广泛的疾病，并显著导致全球感染性疾病相关的发病率和死亡率（1 - 16）（表1）。这些细菌使用几种不同的策略在宿主细胞中复制并影响宿主过程，如膜运输，信号传导途径，代谢，细胞死亡和存活（17 - 19）。广义上讲，细胞内细菌定殖于宿主细胞的两个拓扑结构不同的区域，并根据其细胞内生活方式分为胞质细菌和液泡内细菌。然而，大多数细胞内细菌病原体具有独特的细胞内生命周期，其特征彼此显著不同（图1）。还应该注意的是，液泡内病原体在一定程度上可以进入宿主细胞质，并且细胞质细菌可能在膜结合区室中度过了被低估的细胞内生命周期（20 - 22）。
Intracellular bacterial pathogens cause a wide range of diseases and significantly contribute to the morbidity and mortality associated with infectious diseases worldwide (1‐16) (Table 1). These bacteria use several different strategies to replicate in host cells and influence host processes such as membrane trafficking, signaling pathways, metabolism, cell death, and survival (17‐19). Broadly, intracellular bacteria colonize two topologically distinct regions of the host cell and are divided into cytosolic and intravacuolar bacteria according to their intracellular lifestyle. However, most intracellular bacterial pathogens have unique intracellular life cycles with features strikingly different from one another (Fig. 1). It should also be noted that intravacuolar pathogens gain access to the host cytosol to some extent, and that cytosolic bacteria might spend an underestimated part of their intracellular life cycle within membrane‐bound compartments (20‐22).