Normal levels of histamine and tele-methylhistamine in mast cell-deficient mouse brain.
Normal levels of histamine and tele-methylhistamine in mast cell-deficient mouse brain.
复制标题
肥大细胞缺陷小鼠大脑中组胺和远甲基组胺的正常水平。
DOI：
10.1016/0006-8993(84)90897-7
复制
发表时间：
1984
期刊：
影响因子：
2.9
通讯作者：
Glick,SD
中科院分区：
文献类型：
--
作者：
Hough,LB;Khandelwal,JK;Goldschmidt,RC;Diomande,M;Glick,SD
To determine the contribution by mast cells to the brain content of histamine (HA) and its metabolitetele-methylhistamine (t-MH), the number of mast cells, as well as the levels of HA and t-MH were measured in brain regions of mast cell-deficient (W/Wv) and control (+/+) mice. In agreement with earlier studies, mast cells were identified in control mouse brains, whereas W/Wv) brains were devoid of mast cells. Contrary to earlier studies, no differences between these strains were found in the HA levels of any brain region, implying that mouse brain mast cells do not contribute significantly to brain HA levels. Braint t-MH levels were also not different between strains, except in hypothalamus, where W/Wvlevels were higher; a significantly smaller W/Wvhypothalamus accounted for this difference. It is not certain that such differences are due to the absence of mast cells, since the W/Wvmutant is pleiomorphic, and the biochemical nature of this mutation remains uncertain. However, the absence of mast cells and presence of HA in the W/Wvmouse brain is direct evidence for the existence of non-mast cell HA in the brain. These results also show that mouse brain t-MH levels are predictive of non-mast cell HA in brain.
