EXPRESSION OF DESMIN AND MYOGLOBIN IN RHABDOMYOSARCOMAS AND IN DEVELOPING SKELETAL-MUSCLE
EXPRESSION OF DESMIN AND MYOGLOBIN IN RHABDOMYOSARCOMAS AND IN DEVELOPING SKELETAL-MUSCLE
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DOI：
10.1111/j.1365-2559.1989.tb01624.x
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发表时间：
1989-12-01
期刊：
影响因子：
6.4
通讯作者：
PINKERTON, CR
中科院分区：
文献类型：
--
作者：
CARTER, RL;MCCARTHY, KP;PINKERTON, CR
免疫组化染色结蛋白和肌红蛋白进行了研究，在35横纹肌肉瘤从年轻人和骨骼肌从16人胎儿已知胎龄。29例横纹肌肉瘤表达结蛋白，但6例未分化或低分化肿瘤结蛋白阴性。在结蛋白阳性的病例中，大多数未分化或低分化肉瘤仅表达结蛋白（12/35）。横纹肌母细胞瘤分化增加的肿瘤共表达肌红蛋白（9/35），分化良好的例子也包含横纹（7/35）。8周龄或以下胎儿的骨骼肌主要由原始结蛋白阴性圆形细胞组成。当细胞开始分化时，它们迅速表达结蛋白，并且在大约10周时，表达肌红蛋白并观察到横纹。综合结果加强了这样一种观点，即结蛋白（在年轻人圆细胞肿瘤中严格定义的内容）是横纹肌母细胞分化的可靠标志物。也支持的概念，非常原始的横纹肌肉瘤可能是结蛋白阴性的，虽然这些肿瘤的困难，建立坚定的诊断强调。
Immunohistochemical staining for desmin and myoglobin was investigated in 35 rhabdomyosarcomas from young people and in skeletal muscle from 16 human fetuses of known gestational age. Twenty-nine of the rhabdomyosarcomas expressed desmin but six undifferentiated or poorly-differentiated tumours were desmin negative. Of the desmin positive cases, most undifferentiated or poorly-differentiated sarcomas expressed desmin alone (12/35). Tumours with increasing rhabdomyoblastomic differentiation co-expressed myoglobin (9/35) and well-differentiated examples also contained cross-striations (7/35). Skeletal muscle from fetuses aged 8 weeks or less consisted mainly of primitive desmin negative round cells. As the cells began to differentiate they quickly expressed desmin and, at approximately 10 weeks, myoglobin was expressed and cross-striations were seen. The combined results strengthen the view that desmin (within a strickly defined content of round cell tumours in young people) is a reliable marker for rhabdomyoblastic differentiation. Support is also given to the notion that very primitive rhabdomyosarcomas may be desmin-negative, although the difficulties of establishing firm diagnoses for some of these tumours is emphasized.