L-ARGININE - NITRIC-OXIDE PATHWAY IN ENDOTOXEMIA AND HUMAN SEPTIC SHOCK
L-ARGININE - NITRIC-OXIDE PATHWAY IN ENDOTOXEMIA AND HUMAN SEPTIC SHOCK
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DOI：
10.1097/00003246-199502000-00009
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发表时间：
1995-02-01
影响因子：
8.8
通讯作者：
MONCADA, S
中科院分区：
文献类型：
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作者：
GOMEZJIMENEZ, J;SALGADO, A;MONCADA, S
目的：探讨人类感染性休克中一氧化氮生成、内毒素血症和血流动力学改变之间的关系，设计：前瞻性研究，设置：一所大学转诊医院的 32 个床位的重症监护室，患者：两组休克的脓毒症患者 (n = 13) 或无休克 (n = 16)，以及另一组非脓毒症患者作为对照组 (n = 25)，测量：血浆亚硝酸盐和亚硝酸盐硝酸盐浓度作为一氧化氮生成的指标进行测量，亚硝酸盐和硝酸盐浓度与血浆内毒素和血流动力学变量相关。主要结果：感染性休克患者血浆亚硝酸盐和硝酸盐浓度增加 (p < .01)，亚硝酸盐和硝酸盐与内毒素浓度 r(2) = .21，p < .05) 和心输出量直接相关 (r(2) = .49，p < .05) .05），并且与收缩压成反比（r(2) = .24，p < .01）。结论：这项研究证明了人内毒素性感染性休克中 L-精氨酸：一氧化氮途径的激活，表明一氧化氮可能是这种病理生理情况下血流动力学紊乱的重要介质。
Objective: To investigate the relationship between nitric oxide production, endotoxemia, and hemodynamic alterations in human septic shock,Design: Prospective study,Setting: A 32-bed intensive care unit in a university referral hospital,Patients: Two groups of septic patients with shock (n = 13) or without shock (n = 16) and an additional group of nonseptic patients as control group (n = 25),Measurements: Plasma nitrite and nitrate concentrations were measured as an index of nitric oxide generation, Nitrite and nitrate concentrations were correlated with plasma endotoxin and hemodynamic variables.Main Results: Increased plasma nitrite and nitrate concentrations were found in patients with septic shock (p < .01), Nitrite and nitrate correlated directly with endotoxin concentrations r(2) = .21, p < .05) and cardiac output (r(2) = .49, p < .05), and inversely with systolic blood pressure (r(2) = .24, p < .01).Conclusions: This study demonstrated the activation of the L-arginine:nitric oxide pathway in human endotoxemic septic shock, suggesting that nitric oxide may be an important mediator of the hemodynamic disturbances in this pathophysiologic situation.