Impact of lockdown in COVID 19 on glycemic control in patients with type 1 Diabetes Mellitus
Impact of lockdown in COVID 19 on glycemic control in patients with type 1 Diabetes Mellitus
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DOI：
10.1016/j.dsx.2020.07.016
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发表时间：
2020-09-01
影响因子：
10
通讯作者：
Jangra, Babita
中科院分区：
文献类型：
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作者：
Verma, Anjali;Rajput, Rajesh;Jangra, Babita
背景和目标：COVID 19 是一种影响全球的新型流行病。尽管没有可靠的数据表明控制良好的 1 型糖尿病 (T1DM) 患者感染 SARS-CoV2 患重病的风险增加，但封锁可能会影响需要定期用药和随访的 T1DM 患者。因此，本研究计划观察封锁对 T1DM 患者血糖控制的影响。方法：对 T1DM 患者进行了一项横断面研究，在封锁后 15 天内进行了结构化问卷随访。收集了有关低血糖和高血糖发作、糖尿病酮症酸中毒 (DKA)、漏服胰岛素剂量、定期血糖监测、饮食依从性、体力活动、封锁期间住院治疗的数据。将锁定阶段的平均血糖和 HbA1C 与锁定前的读数进行比较。结果：52 名患者中，36.5% 出现高血糖，15.3% 出现低血糖。 26.9% 的人漏服了胰岛素，36.5% 的人没有定期进行血糖监测，17.4% 的人在封锁期间没有遵守饮食规定。锁定阶段的平均血糖为 276.9 +/- 64.7 mg/dl，而锁定前阶段的平均血糖为 212.3 +/- 57.9 mg/dl。封锁期间的平均 HbA1c 值 (10 +/- 1.5%) 远高于封锁前的平均 HbA1c 值 (8.8 +/- 1.3%)，差异具有统计学意义 (p < 0.05)。结论：T1DM 患者的血糖控制恶化主要是由于封锁期间无法使用胰岛素/糖贴。未来需要做好准备，以尽量减少并发症。 (C) 2020 年印度糖尿病。由爱思唯尔有限公司出版。保留所有权利。
Background and aims: COVID 19 is a novel pandemic affecting globally. Although no reliable data suggests that patients of well controlled Type 1 Diabetes Mellitus (T1DM) being at increased risk of becoming severely ill with SARS-CoV2, but lockdown may impact patients with T1DM requiring regular medications and follow up. Hence this study was planned to see the impact of lockdown on glycemic control in patients with T1DM.Methods: A cross sectional study was done in T1DM patients in whom a structured questionnaire was administered on follow up within 15 days after lockdown. Data regarding hypoglycemic and hyperglycemic episodes, Diabetic ketoacidosis (DKA), insulin dose missed, regular glucose monitoring, dietary compliance, physical activity, hospitalization during the phase of lockdown was taken. Average blood glucose and HbA1C of lockdown phase was compared with the readings of prelockdown phase.Results: Out of 52 patients, 36.5% had hyperglycemic and 15.3% had hypoglycemic episodes. Insulin dose was missed in 26.9%, glucose monitoring not done routinely in 36.5% and 17.4% were not diet compliant during lockdown. Average blood glucose during lockdown phase was 276.9 +/- 64.7 mg/dl as compared to 212.3 +/- 57.9 mg/dl during prelockdown phase. Mean HbA1c value of lockdown (10 +/- 1.5%) which was much higher that of pre lockdown (8.8 +/- 1.3%) and the difference was statistically significant (p < 0.05).Conclusion: Glycemic control of T1DM patients has worsened mainly due to non availability of insulin/ glucostrips during lockdown period. There is a need for preparedness in future so that complications can be minimised. (C) 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.