Poor medication adherence to bisphosphonates and high self-perception of aging in elderly female patients with osteoporosis
Poor medication adherence to bisphosphonates and high self-perception of aging in elderly female patients with osteoporosis
复制标题
老年女性骨质疏松症患者双磷酸盐用药依从性差且对衰老的自我认知较高
DOI：
10.1007/s00198-016-3763-8
复制
发表时间：
2016-09
影响因子：
4
通讯作者：
Wu X. N.
中科院分区：
文献类型：
--
作者：
Wu X.;Wei D.;Sun B.;Wu X. N.
摘要不坚持使用双膦酸类药物会增加老年女性骨质疏松症患者骨折的风险。这是首批探索服药依从性和自我衰老感知之间关系的研究之一。结论老年女性骨质疏松症患者服药依从性差，对双磷酸盐的服药依从性与自感衰老之间的关系。随机抽取中国3所三级医院245例老年女性骨质疏松症患者常规口服双膦酸类药物治疗。收集社会人口学和骨质疏松症相关资料、Morisky用药依从性量表-8(MMAS-8)和老年认知问卷(APQ)数据。服药依从性好和差的比例分别为28.6%和71.4%，说明服药依从性较差。APQ的六个领域与服药依从性在统计学上显著相关。有趣的是，在多元线性回归模型中，控制年龄、教育程度、婚姻状况和伴随骨质疏松的症状作为协变量，三个领域的影响消失了。结论老年女性骨质疏松症患者的服药依从性较差的因素包括缺乏控制感、对负性事件的期望值较高、对骨质疏松症的慢性持续期性质及其与年龄的关联有更高的信念。需要解决对衰老自我感知的担忧，以提高服药依从性。
SummaryNon-adherence to bisphosphonates exposes the elderly female osteoporosis patients to an increased risk of fracture. This was one of the first studies to explore the relationship between medication adherence and self-perception of aging. Feelings of lacking control and expectations for negative events, beliefs of illness’s chronic duration nature, and its linkage with aging were associated with of poor medication adherence.IntroductionTo examine the relationship between medication adherence to bisphosphonates and self-perception of aging in elderly female patients with osteoporosis.MethodsThis was a cross-sectional survey. A convenience sample of 245 elderly female patients with osteoporosis prescribed regular oral bisphosphonate therapy was recruited from three tertiary hospitals in China. Sociodemographic and osteoporosis-related data, Morisky Medication Adherence Scale-8 (MMAS-8) and Aging Perceptions Questionnaire (APQ) data were collected.ResultsMean adherence score measured by MMAS-8 was 4.46(SD = 1.91; range, 0.25–7.00). Percentages of good and poor adherence were 28.6 and 71.4 %, which showed a poor medication adherence. Six domains of APQ statistically significantly associated with medication adherence. Interestingly, with control ofage,educational status,marital status,and symptoms accompanying osteoporosisas covariates in the multivariate linear regression model, the effects of three domains disappeared. Significantly, worse adherence was observed in those patients who had higher feelings of lack of control, more expectations for negative events, more beliefs of osteoporosis’s chronic duration nature and its linkage with aging.ConclusionsWe conclude that feelings of lacking control, expectations for negative events, beliefs of illness’s chronic duration nature, and its linkage with aging were associated with poor medication adherence in elderly female patients with osteoporosis. Concerns about self-perception of aging need to be addressed in order to improve medication adherence.
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影响因子：
4.1
作者：
Ingrand I;Houeto JL;Gil R;Mc Gee H;Ingrand P;Paccalin M
通讯作者：
Paccalin M
影响因子：
3.7
作者：
Robertson DA;Savva GM;King-Kallimanis BL;Kenny RA
通讯作者：
Kenny RA
中国老年人对衰老的自我认知与降压药物依从性之间的关系
影响因子：
4
作者：
Hou, Yunying;Zhang, Dandan;Wang, Xiaohua
通讯作者：
Wang, Xiaohua
影响因子：
5.9
作者：
Miller, Nancy Houston
通讯作者：
Miller, Nancy Houston
影响因子：
4
作者：
Carr, A. J.;Thompson, P. W.;Cooper, C.
通讯作者：
Cooper, C.