HAART slows progression to anal cancer in HIV-infected MSM
HAART slows progression to anal cancer in HIV-infected MSM
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DOI：
10.1097/qad.0000000000000537
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发表时间：
2015-01-28
期刊：
影响因子：
3.8
通讯作者：
Press, Natasha M.
中科院分区：
文献类型：
--
作者：
Duncan, Katrina C.;Chan, Keith J.;Press, Natasha M.
目的：抗逆转录病毒药物不能预防肛门上皮内瘤变。然而，抗逆转录病毒药物在浸润性肛门癌自然史中的影响尚不清楚。目的是探讨抗逆转录病毒药物对HIV阳性MSM肛门癌发生时间的影响。设计：回顾性分析1988年至2008年接受抗逆转录病毒药物治疗的HIV阳性MSM队列中肛门癌病例。方法：采用考克斯回归和Kaplan-Meier曲线分析从首次CD 4（+）细胞计数或HIV RNA病毒载量检测到肛门癌诊断的时间。在HAART之前接受治疗的肛门癌病例（
Objective: Antiretrovirals do not prevent anal intraepithelial neoplasia. However, the influence of antiretrovirals in the natural history of invasive anal cancer is less clear. The objective is to investigate the impact of antiretrovirals in the time to the development of anal cancer in HIV-positive MSM.Design: A retrospective analysis of cases of anal cancer in a cohort of HIV-positive MSM receiving antiretrovirals between 1988 and 2008.Methods: Time from first CD4(+) cell count or HIV RNA viral load test to anal cancer diagnosis was analysed using Cox regression and Kaplan-Meier curves. Anal cancer cases treated in the era prior to HAART (