Hyaluronic acid in progressive systemic sclerosis
Hyaluronic acid in progressive systemic sclerosis
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DOI：
10.1159/000246314
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发表时间：
1996-01-01
期刊：
影响因子：
3.4
通讯作者：
Rodrigo, FG
中科院分区：
文献类型：
--
作者：
Freitas, JP;Filipe, P;Rodrigo, FG
背景：进行性系统性硬化症(PSS)患者糖胺多糖代谢紊乱。血清透明质酸(HA)在本病中升高。目的：根据疾病的不同阶段测定PSS患者的血浆HE浓度。方法：48例患者分为3个亚组：亚组1(n=10)，有皮肤受累而无其他器官受累；亚组2(n=21)，有皮肤和食道受累；亚组3(n=17)，有皮肤、肺和其他脏器受累。用放射测定法测定HA的含量。结果：我们的结果证实了PSS患者血浆HA的升高。他们还表明，肺部受累是导致血浆中HA浓度高的主要特征。患者血浆HA水平较正常人升高(P<；0.001)。亚组1与亚组3之间、亚组2与亚组3之间均有显著差异(p<；0.01)，病情严重程度评分与血浆HA呈正相关(p<；0.01)。结论：血浆HA水平升高可作为判断病情严重程度、压迫程度和脏器受累程度的血清学指标。
Background: The glycosaminoglycans metabolism is disturbed in progressive systemic sclerosis (PSS). Serum hyaluronic acid (HA) is elevated in this disease. Objective: This study was conducted to determine the HE plasma concentrations of patients with PSS according to the different stages of the disease. Methods: We studied 48 patients divided into three subgroups: subgroup 1 (n = 10), with skin compromise without evidence of other organ involvement; subgroup 2 (n = 21), with skin and esophagus involvement; subgroup 3 (n = 17), with skin, lung and other internal organ involvement. A radiometric assay was performed for quantification of HA. Results: Our results confirm the increase in plasma HA in patients with PSS. They also suggest that lung involvement is the main feature responsible for high plasma concentrations of HA. The plasma HA levels were elevated in patients compared to normals (p < 0.001). Significant differences were observed between subgroups 1 and 3 (p < 0.01) and between subgroups 2 and 3 (p < 0.01), A positive correlation between disease severity scores and plasma HA values was observed (p < 0.01). Conclusion: An important elevation of HA plasma levels could be a serologic marker of disease severity, propression and degree of visceral involvement.