Ultraflexible organic amplifier with biocompatible gel electrodes.
Ultraflexible organic amplifier with biocompatible gel electrodes.
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DOI：
10.1038/ncomms11425
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发表时间：
2016-04-29
影响因子：
16.6
通讯作者：
Someya T
中科院分区：
文献类型：
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作者：
Sekitani T;Yokota T;Kuribara K;Kaltenbrunner M;Fukushima T;Inoue Y;Sekino M;Isoyama T;Abe Y;Onodera H;Someya T
在体电子监测系统是获得高时空分辨率和灵敏度的生物信号的有前途的技术。在这里，我们展示了生物相容性高导电凝胶复合材料的制造，包括多壁碳纳米管分散片与水凝胶。该凝胶复合物表现出100 mS cm-2的导纳，并且即使在低频范围内也保持高导纳。在植入活体皮下组织4周后，与广泛使用的金属电极相比，它显示出较小的异物反应。利用多功能凝胶复合材料，我们在1.2 μ m厚的聚萘二甲酸乙二醇酯薄膜上制备了一种可折叠和机械柔性的有机有源矩阵放大器，用于放大（放大因子：200）微弱的生物信号。该复合材料集成到放大器中，以实现直接导联心外膜心电图，该心电图很容易分布在不均匀的心脏组织上。 柔性电子设备有望通过植入设备监测生物活性。在这里，作者开发了一种生物相容的导电碳纳米管/凝胶复合材料，并将其与一个可弯曲的放大器耦合，使心外膜心电图信号的体内测量成为可能。
In vivo electronic monitoring systems are promising technology to obtain biosignals with high spatiotemporal resolution and sensitivity. Here we demonstrate the fabrication of a biocompatible highly conductive gel composite comprising multi-walled carbon nanotube-dispersed sheet with an aqueous hydrogel. This gel composite exhibits admittance of 100 mS cm−2 and maintains high admittance even in a low-frequency range. On implantation into a living hypodermal tissue for 4 weeks, it showed a small foreign-body reaction compared with widely used metal electrodes. Capitalizing on the multi-functional gel composite, we fabricated an ultrathin and mechanically flexible organic active matrix amplifier on a 1.2-μm-thick polyethylene-naphthalate film to amplify (amplification factor: ∼200) weak biosignals. The composite was integrated to the amplifier to realize a direct lead epicardial electrocardiography that is easily spread over an uneven heart tissue. Flexible electronics promise the opportunity to monitor biological activity via implanted devices. Here, the authors develop a biocompatible conductive carbon nanotube/gel composite and couple it with an ultrathin flexible amplifier, enabling in vivo measurement of epicardial electrocardiogram signals.