Association of Efficacy of Resistance Exercise Training With Depressive Symptoms Meta-analysis and Meta-regression Analysis of Randomized Clinical Trials
Association of Efficacy of Resistance Exercise Training With Depressive Symptoms Meta-analysis and Meta-regression Analysis of Randomized Clinical Trials
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抗阻运动训练的效果与抑郁症状的关系 随机临床试验的 Meta 分析和 Meta 回归分析
DOI：
10.1001/jamapsychiatry.2018.0572
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发表时间：
2018-06-01
期刊：
影响因子：
25.8
通讯作者：
Herring, Matthew P.
中科院分区：
文献类型：
--
作者：
Gordon, Brett R.;McDowell, Cillian P.;Herring, Matthew P.
重要性 阻力运动训练 (RET) 对身体的益处已有详细记录，但关于 RET 与心理健康结果的关系却知之甚少。迄今为止，尚未对 RET 的抗抑郁作用进行定量综合。 目的 估计 RET 功效与抑郁症状的关联，并确定逻辑、理论和/或先前经验变量与抑郁症状相关的程度，以及 RET 功效与抑郁症状的关联是否解释了总体效应大小的变异性。 数据来源 2017 年 8 月之前发表的文章，使用 Google Scholar、MEDLINE、PsycINFO、 PubMed 和 Web of Science。 研究选择 随机临床试验包括随机分组至 RET (n = 947) 或非主动对照条件 (n = 930)。 数据提取和合成 计算对冲 d 效应大小，并使用随机效应模型进行所有分析。进行荟萃回归以量化参与者和试验特征的潜在调节影响。 主要结果和措施随机临床试验使用在基线和干预中期和/或干预后评估的抑郁症状的有效措施。事先选择了四位主要调节者，以提供有关效果大小变化的重点研究假设：处方 RET 的总量、参与者是否健康或身体或精神疾病、分配和/或评估是否盲法、以及 RET 干预是否导致强度显着改善。 结果 54 个效果来自涉及 1877 名参与者的 33 项随机临床试验。抗阻运动训练与抑郁症状的显着减轻相关，且平均效果中等。 0.66（95% CI，0.48-0.83；z = 7.35；P
IMPORTANCE The physical benefits of resistance exercise training (RET) arewell documented, but less is knownregarding the association of RET with mental health outcomes. To date, no quantitative synthesis of the antidepressant effects of RET has been conducted.OBJECTIVES To estimate the association of efficacy of RET with depressive symptoms and determine the extent to which logical, theoretical, and/or prior empirical variables are associated with depressive symptoms and whether the association of efficacy of RET with depressive symptoms accounts for variability in the overall effect size.DATA SOURCES Articles published before August 2017, located using Google Scholar, MEDLINE, PsycINFO, PubMed, andWeb of Science.STUDY SELECTION Randomized clinical trials included randomization to RET (n = 947) or a nonactive control condition (n = 930).DATA EXTRACTION AND SYNTHESIS Hedges d effect sizeswere computed and random-effects models were used for all analyses. Meta-regression was conducted to quantify the potential moderating influence of participant and trial characteristics.MAIN OUTCOMES AND MEASURES Randomized clinical trials used validated measures of depressive symptoms assessed at baseline and midintervention and/or postintervention. Four primary moderators were selected a priori to provide focused research hypotheses about variation in effect size: total volume of prescribed RET, whether participants were healthy or physically or mentally ill, whether or not allocation and/or assessment were blinded, and whether or not the RET intervention resulted in a significant improvement in strength.RESULTS Fifty-four effects were derived from 33 randomized clinical trials involving 1877 participants. Resistance exercise training was associated with a significant reduction in depressive symptoms with a moderate-sized mean effect. of 0.66 (95% CI, 0.48-0.83; z = 7.35; P