hOGG1 Ser326Cys polymorphism is associated with risk of bladder cancer in a Chinese population: A case-control study
hOGG1 Ser326Cys polymorphism is associated with risk of bladder cancer in a Chinese population: A case-control study
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hOGG1 Ser326Cys 多态性与中国人群膀胱癌风险相关：病例对照研究
DOI：
10.1111/j.1349-7006.2012.02290.x
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发表时间：
2012-07-01
期刊：
影响因子：
5.7
通讯作者：
Zhang, Zhengdong
中科院分区：
文献类型：
--
作者：
Ma, Lan;Chu, Haiyan;Zhang, Zhengdong
人氧代鸟嘌呤糖基化酶1（hOGG 1）是一种DNA修复酶，在碱基切除修复（BER）途径中发挥重要作用。多项研究报道了hOGG 1基因的Ser 326 Cys（rs 1052133）多态性与膀胱癌易感性的关系。我们假设该多态性与中国人群中膀胱癌的风险相关。在1050例组织学确诊的膀胱癌患者和1404名年龄和性别匹配的健康对照的病例对照研究中，我们使用TaqMan技术对hOGG 1 Ser 326 Cys多态性进行基因分型，并评估其与膀胱癌风险的相关性。我们发现hOGG 1 Ser/Cys相似+相似Ser/Ser基因型与膀胱癌风险显著增加相关（校正比值比[OR]相似=相似1.19，95%置信区间[CI]相似=相似1.011.41），与Cys/Cys基因型相比。此外，在65岁以上的受试者中，（OR相似=相似1.31，95% CI相似=相似1.041.66），男性受试者（OR相似=相似1.21，95% CI相似=相似1.001.47），曾吸烟者（OR相似=相似1.29，95%CI相似=相似1.001.68）和重度吸烟者（>20包年）（OR相似=相似1.45，95%CI相似=相似1.032.04）。在膀胱癌的肿瘤分级和肿瘤分期分层中未观察到显著相关性。结论：hOGG 1基因Ser 326 Cys多态性可能与中国人群膀胱癌的易感性有关。（Cancer Sci 2012; 103：12151220）
Human oxoguanine glycosylase 1 (hOGG1) is a DNA repair enzyme, which plays important roles in the base excision repair (BER) pathway. Several studies reported a common polymorphism Ser326Cys (rs1052133) in hOGG1, which conferred the susceptibility of bladder cancer. We hypothesized that the polymorphism is associated with risk of bladder cancer in a Chinese population. In a case-control study of 1050 histologically confirmed bladder cancer patients and 1404 age and sex matched healthy controls, we genotyped the hOGG1 Ser326Cys polymorphism using TaqMan technology and assessed its association with bladder cancer risk. We found that the hOGG1 Ser/Cys similar to+similar to Ser/Ser genotypes were associated with a significantly increased risk of bladder cancer (adjusted odds ratio [OR]similar to=similar to 1.19, 95% confidence interval [CI]similar to=similar to 1.011.41), compared with the Cys/Cys genotype. Furthermore, the increased risk was more pronounced among subjects over age 65 similar to years (OR similar to=similar to 1.31, 95% CI similar to=similar to 1.041.66), male subjects (OR similar to=similar to 1.21, 95% CI similar to=similar to 1.001.47), ever smokers (OR similar to=similar to 1.29, 95% CI similar to=similar to 1.001.68) and heavy smokers (>20 pack-years) (OR similar to=similar to 1.45, 95% CI similar to=similar to 1.032.04). No significant association was observed in the stratification of tumor grade and tumor stage for bladder cancer. In conclusion, our results suggest that hOGG1 Ser326Cys polymorphism may contribute to the susceptibility to bladder cancer in a Chinese population. (Cancer Sci 2012; 103: 12151220)