Functional recovery in a primate model of Parkinson's disease following motor cortex stimulation
Functional recovery in a primate model of Parkinson's disease following motor cortex stimulation
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DOI：
10.1016/j.neuron.2004.11.023
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发表时间：
2004-12-02
期刊：
影响因子：
16.2
通讯作者：
Palfi, S
中科院分区：
文献类型：
--
作者：
Drouot', X;Oshino, S;Palfi, S
帕金森氏病的一个概念假设运动皮层可能在基底神经节中形成异常的节律活动，这是观察到的运动症状发生的基础。我们使用慢性MPTP灵长类动物模型进行了初级运动皮层电干扰的临床前研究，其中多巴胺耗竭是进行性的，并定期使用F-18-DOPA正电子断层扫描记录。高频运动皮层刺激显着减少运动不能和运动迟缓。这种行为益处与18-F-脱氧葡萄糖PET评估的补充运动区的代谢活性增加、内苍白球（GPi）和丘脑底核（GPi）的平均放电率正常化以及这两个结构中同步振荡神经元活动的减少相关。运动皮层刺激是一种简单而安全的方法，可以调节丘脑底-苍白球-皮层环，减轻帕金森病症状，而不需要进行脑深部立体定向手术。
A concept in Parkinson's disease postulates that motor cortex may pattern abnormal rhythmic activities in the basal ganglia, underlying the genesis of observed motor symptoms. We conducted a preclinical study of electrical interference in the primary motor cortex using a chronic MPTP primate model in which dopamine depletion was progressive and regularly documented using F-18-DOPA positron tomography. High-frequency motor cortex stimulation significantly reduced akinesia and bradykinesia. This behavioral benefit was associated with an increased metabolic activity in the supplementary motor area as assessed with 18-F-deoxyglucose PET, a normalization of mean firing rate in the internal globus pallidus (GPi) and the subthalamic nucleus (STN), and a reduction of synchronized oscillatory neuronal activities in these two structures. Motor cortex stimulation is a simple and safe procedure to modulate subthalamo-pallido-cortical loop and alleviate parkinsonian symptoms without requiring deep brain stereotactic surgery.