Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters
Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters
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DOI：
10.1016/j.bbrc.2007.12.140
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发表时间：
2008-02-29
影响因子：
3.1
通讯作者：
Ha, Tae Youl
中科院分区：
文献类型：
--
作者：
Cho, Il Jin;Ahn, Ji Yun;Ha, Tae Youl
我们研究了白藜芦醇的降血脂作用，重点是在高脂饮食的仓鼠的mRNA表达和肝脏HMG-CoA还原酶（HMGR）的活性。雄性叙利亚金仓鼠喂食含有0.025%非诺贝特或0.025%白藜芦醇的高脂肪饲料8周。白藜芦醇组血清总胆固醇和甘油三酯浓度显著低于对照组。含白藜芦醇的饲料显著降低Apo B、Lp（a）和胆固醇酯转运蛋白（CETP）的浓度，但升高Apo A-I水平和Apo A-I/Apo B比值。白藜芦醇组肝组织胆固醇和甘油三酯含量显著低于对照组。Real-time PCR分析显示，白藜芦醇组HMGR mRNA表达明显低于对照组。这些结果表明，饮食白藜芦醇降低血清胆固醇通过下调肝脏HMGR mRNA的表达在高脂饮食喂养的仓鼠。(C)2007年爱思唯尔公司All rights reserved.
We investigated the hypolipidemic effect of resveratrol focused on the mRNA expression and hepatic HMG-CoA reductase (HMGR) activity in hamsters fed a high-fat diet. Male Syrian Golden hamsters were fed a high-fat diet containing 0.025% fenofibrate or 0.025% resveratrol for 8 weeks. The concentrations of serum total cholesterol and triglyceride were significantly lower in the resveratrol-fed group than in the control group. The resveratrol contained diet significantly decreased Apo B, Lp(a), and cholesterol-ester transport protein (CETP) concentrations, but increased Apo A-I levels and the Apo A-I/Apo B ratio. The contents of cholesterol and triglyceride in hepatic tissue were significantly lower in the resveratrol group than in the control group. Real-time PCR analysis revealed that HMGR mRNA expression was significantly lower in the resveratrol group than in the control group. These results indicate that dietary resveratrol reduces serum cholesterol by down-regulating hepatic HMGR mRNA expression in hamsters fed a high-fat diet. (C) 2007 Elsevier Inc. All rights reserved.