Impact of EASO/ESPEN-Defined Sarcopenic Obesity Following a Technology-Based Weight Loss Intervention.
Impact of EASO/ESPEN-Defined Sarcopenic Obesity Following a Technology-Based Weight Loss Intervention.
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基于技术的减肥干预后 EASO/ESPEN 定义的肌少症肥胖的影响。
DOI：
10.1007/s00223-023-01138-4
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发表时间：
2024
影响因子：
4.2
通讯作者：
Batsis,JohnA
中科院分区：
文献类型：
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作者：
Wood,BrianS;Batchek,DakotaJ;Lynch,DavidH;Spangler,HillaryB;Gross,DanaeC;Petersen,CurtisL;Batsis,JohnA
肉源性肥胖症是脂肪组织增加(肥胖)和肌肉质量或力量减少(肌肉量减少)并存的现象，与单纯肥胖相比，其预后更差。新的EASO/Espen共识为其定义标准化提供了一个框架。这项研究试图评估在使用这些新定义参加多组分减肥干预的老年人中，有没有观察到有和没有石膏性肥胖的老年人在体重减轻或身体功能方面是否存在初步差异。方法从2018年到2020年，在65岁的成年人中进行了一项为期6个月的非随机、非盲目、单臂先导研究，体重指数( ≥ ≥ )为30 mg/m2。每周一次的营养师会诊和每周两次的物理治疗师指导的锻炼课程是通过远程医疗提供的。我们对父母研究(n= 53人入选，n= 44人完成)进行了二次回顾分析，调查了在农村肥胖老年人中进行基于技术的体重管理干预的可行性。在这里，我们应用了五种骨性肥胖症的定义(在共识中概述)，以确定有和没有骨性肥胖者对干预的反应是否不同。评估的主要结果包括体重减轻和身体功能(30名S坐着到站立)。结果在母研究中，平均体重减轻为−4.6g(95%CI−3.6，−5.6；p<； 0.001)。30名S患者的坐立动作平均增加3.1%(+ 为1.9%， + 为4.3%；p<； 为0.001)。在这项目前的分析中，体重显著下降，基线和随访之间的重复次数增加，在每一组有或没有石棺减少的个体中，每一种拟议的定义。然而，我们没有观察到从基线到随访组之间的任何显著差异。结论在参加减肥干预的有无骨钙性肥胖的老年人中，潜在的体重减轻或身体功能没有显著差异，这可能表明设计良好的多组分干预措施可以导致类似的结果，无论肥胖者的骨质疏松症状况如何。为了证实这些初步结果，迫切需要进行完全有效的随机临床试验。
BackgroundSarcopenic Obesity is the co-existence of increased adipose tissue (obesity) and decreased muscle mass or strength (sarcopenia) and is associated with worse outcomes than obesity alone. The new EASO/ESPEN consensus provides a framework to standardize its definition. This study sought to evaluate whether there are preliminary differences observed in weight loss or physical function in older adults with and without sarcopenic obesity taking part in a multicomponent weight loss intervention using these new definitions.MethodsA 6-month, non-randomized, non-blinded, single-arm pilot study was conducted from 2018 to 2020 in adults ≥ 65 years with a body mass index (BMI) ≥ 30 kg/m2. Weekly dietitian visits and twice-weekly physical therapist-led exercise classes were delivered using telemedicine. We conducted a secondary retrospective analysis of the parent study (n= 53 enrolled,n= 44 completers) that investigated the feasibility of a technology-based weight management intervention in rural older adults with obesity. Herein, we applied five definitions of sarcopenic obesity (outlined in the consensus) to ascertain whether the response to the intervention differed among those with and without sarcopenic obesity. Primary outcomes evaluated included weight loss and physical function (30-s sit-to-stand).ResultsIn the parent study, mean weight loss was − 4.6 kg (95% CI − 3.6, − 5.6;p< 0.001). Physical function measures of 30-s sit-to-stand showed a mean increase of 3.1 in sit-to-stand repetitions (+ 1.9, + 4.3;p< 0.001). In this current analysis, there was a significant decrease in weight and an increase in repetitions between baseline and follow-up within each group of individuals with and without sarcopenia for each of the proposed definitions. However, we did not observe any significant differences in the changes between groups from baseline to follow-up.ConclusionsThe potential lack of significant differences in weight loss or physical function between older adults with and without sarcopenic obesity participating in a weight loss intervention may suggest that well-designed, multicomponent interventions can lead to similar outcomes irrespective of sarcopenia status in persons with obesity. Fully powered randomized clinical trials are critically needed to confirm these preliminary results.