A case report of acquired hemophilia following COVID-19 vaccine
A case report of acquired hemophilia following COVID-19 vaccine
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DOI：
10.1111/jth.15291
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发表时间：
2021-05-10
影响因子：
10.4
通讯作者：
Farsi, Sara
中科院分区：
文献类型：
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作者：
Radwi, Mansoor;Farsi, Sara
获得性 A 型血友病 (AHA) 是一种罕见的出血性疾病，通常与恶性肿瘤、自身免疫性疾病或妊娠有关。我们报告了一名 69 岁的男士在接受 COVID-19 疫苗后出现出血症状的病例。实验室检查显示活化部分凝血活酶时间单独延长，冯维勒布兰德因子正常。进一步测试证实了因子 VIII 抑制剂的存在。迄今为止，尚未报告因接触 COVID-19 疫苗而出现 AHA 病例。已有两例在季节性流感和 H1N1 疫苗接种后出现 AHA 病例，以及两例在感染 COVID-19 后出现 AHA 病例。我们总结了这些病例并回顾了疫苗接种后自身免疫反应的文献。
Acquires hemophilia A (AHA) is rare bleeding condition commonly associated with malignancy, autoimmune disease, or pregnancy. We report a case of a 69-year-old gentleman who developed bleeding symptoms after receiving COVID-19 vaccine. Laboratory testing showed isolated prolongation of the activated partial thromboplastin time, and normal von Willebrand factor. Further testing confirmed the presence of factor VIII inhibitor. To date, no cases of AHA have been reported after exposure to COVID-19 vaccine. There have been two cases of AHA following seasonal flu and H1N1 vaccination, as well as two cases of AHA following COVID-19 infection. We present a summary of these cases and review of literature of autoimmune reactions following vaccination.