High frequencies of α-thalassaemia are the result of natural selection by malaria
High frequencies of α-thalassaemia are the result of natural selection by malaria
复制标题
α-地中海贫血的高发率是疟疾自然选择的结果
作者：
J. Flint;A. Hill;D. Bowden;S. Oppenheimer;P. R. Sill;S. Serjeantson;J. Bana;K. Bhatia;M. Alpers;A. J. Boyce;D. Weatherall;J. Clegg
α+-地中海贫血的发生率（而非其他非连锁DNA多态性）与整个美拉尼西亚的疟疾地方病具有高度和纬度依赖性相关性，支持了以下假设：对这种寄生虫病的保护是导致世界许多地区血红蛋白病高发的主要因素。
The frequency of α+-thalassaemia, but not other unlinked DNA polymorphisms, exhibits an altitude- and latitude-dependent correlation with malaria endemicity throughout Melanesia, supporting the hypothesis that protection against this parasitic disease is the major factor responsible for the high frequencies of haemoglobinopathies in many parts of the world.
体外恶性疟原虫：血红蛋白 H 病红细胞生长减少。
影响因子：
20.3
作者：
Ifediba,TC;Stern,A;Ibrahim,A;Rieder,RF
通讯作者：
Rieder,RF