Evaluation of neuromedin U actions in energy homeostasis and pituitary function
Evaluation of neuromedin U actions in energy homeostasis and pituitary function
复制标题
DOI：
10.1210/en.2002-220121
复制
发表时间：
2002-10-01
期刊：
影响因子：
4.8
通讯作者：
Luckman, SM
中科院分区：
文献类型：
--
作者：
Ivanov, TR;Lawrence, CB;Luckman, SM
脑肠肽神经素U （NMU）最近被确定为食物摄入的生理调节剂。为了进一步研究NMU在能量稳态中的核心作用，我们检测了NMU转录本的分布以及脑室内给药对几个生理参数和c-Fos激活模式的影响。在这里，我们报告了24小时禁食大鼠的脑室内给予NMU导致随后的食物摄入量减少和体重增加。NMU激活了与摄食行为调节有关的几个大脑区域的神经元。活化细胞包括弓状核和脑干的儿茶酚胺能神经元。分布研究显示NMU在尾侧脑干（孤立束核和下橄榄核）和垂体中表达，在结节部有显著水平。这与早先发表的观察结果相矛盾。在肥胖（fa/fa） Zucker大鼠中，在孤立束核、结节部和远端部检测到NMU表达减少，而在禁食大鼠中，在远端部检测到NMU转录减少。这些结果证实了NMU对摄食的影响，并提示NMU在神经内分泌功能中的其他作用。
The brain-gut peptide neuromedin U (NMU) has been identified recently as a physiological regulator of food intake. To further investigate the central role of NMU in energy homeostasis, we examined the distribution of NMU transcript and the effect of intracerebroventricular administration on several physiological parameters and on the pattern of c-Fos activation. Here we report that intracerebroventricular administration of NMU to 24-h fasted rats resulted in a decrease in subsequent food intake and body weight gain. NMU administration activated neurons in several brain regions implicated in the regulation of feeding behavior. Activated cells included catecholaminergic neurons of the arcuate nucleus and brain stem. Distribution studies revealed NMU expression in the caudal brain stem (nucleus of the solitary tract and inferior olive) and pituitary, with significant levels in the pars tuberalis. This contradicts earlier published observations. In obese (fa/fa) Zucker rats, decreases in NMU expression were detected in the nucleus of the solitary tract, pars tuberalis, and pars distalis, whereas in the fasted rat, a decrease in NMU transcript was detected in the pars distalis. These results, confirm the effects of NMU on feeding and suggest additional roles for NMU in neuroendocrine function.