Frequent hepatitis C virus superinfection in injection drug users
Frequent hepatitis C virus superinfection in injection drug users
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DOI：
10.1086/424491
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发表时间：
2004-10-15
影响因子：
6.4
通讯作者：
Delwart, EL
中科院分区：
文献类型：
--
作者：
Herring, BL;Page-Shafer, K;Delwart, EL
The frequency of hepatitis C virus (HCV) superinfection with a divergent viral strain was determined in a cohort of recently infected young injection drug users (IDUs) with an HCV incidence rate of 25%. HCV was amplified, by use of polymerase chain reaction (PCR), from plasma samples collected from 25 HCV-infected individuals over an average period of 12 months, and their viral sequences were compared. Phylogenetic analysis identified 5 IDUs with superinfection (20%) occurring after seroconversion: 2 IDUs were superinfected with different HCV genotypes, and 3 were superinfected with divergent strains of the same genotype. The superinfecting strains were not detected as minority variants (
