Inflammaging and Frailty Status Do Not Result in an Increased Extracellular Vesicle Concentration in Circulation.
Inflammaging and Frailty Status Do Not Result in an Increased Extracellular Vesicle Concentration in Circulation.
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DOI：
10.3390/ijms17071168
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发表时间：
2016-07-20
影响因子：
5.6
通讯作者：
Otaegui D
中科院分区：
文献类型：
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作者：
Alberro A;Sáenz-Cuesta M;Muñoz-Culla M;Mateo-Abad M;Gonzalez E;Carrasco-Garcia E;Araúzo-Bravo MJ;Matheu A;Vergara I;Otaegui D
在过去的几十年中，细胞外囊泡（EV）已成为细胞间通讯的关键参与者。就炎症而言，多项研究报告称，炎症发作期间循环中的 EV 水平升高。基于此，我们研究了衰老是否会导致 EV 数量升高，因为在老年人中已描述了一种称为“炎症”的基础促炎症状态。此外，我们还假设老年人的虚弱和依赖状况可能会影响血浆中EV的浓度。结果表明，炎症、虚弱或依赖状态不会导致 EV 增加，至少不会导致循环中 EV 总数的增加。这些结果为研究电动汽车在人类衰老和炎症过程中的作用开辟了新的视角。
In the last decades extracellular vesicles (EVs) have emerged as key players for intercellular communication. In the case of inflammation, several studies have reported that EV levels are increased in circulation during inflammatory episodes. Based on this, we investigated whether aging results in elevated EV number, as a basal proinflammatory status termed “inflammaging” has been described in aged individuals. Moreover, we also hypothesized that frailty and dependence conditions of the elderly could affect EV concentration in plasma. Results showed that inflammaging, frailty or dependence status do not result in EV increase, at least in the total number of EVs in circulation. These results open a new perspective for investigating the role of EVs in human aging and in the inflammaging process.