Association of IL-10 receptor 2 (IL10RB) SNP with systemic sclerosis
Association of IL-10 receptor 2 (IL10RB) SNP with systemic sclerosis
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DOI：
10.1016/j.bbrc.2008.06.054
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发表时间：
2008-08-29
影响因子：
3.1
通讯作者：
Tsuchiya, Naoyuki
中科院分区：
文献类型：
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作者：
Hikami, Koki;Ehara, Yukikazu;Tsuchiya, Naoyuki
白介素 10 (IL-10) 信号传导被认为在系统性硬化症 (SSc) 中发挥作用。 IL10RB 编码 IL-10 受体 2 (IL-10R2)，这是 IL-10、IL-22、IL-26 和干扰素 (IFN)-γ 受体复合物的共享成分。在这项研究中，我们检查了 IL10RB 多态性与 SSc 易感性的关联。 rs2834167 (47K/K) 的基因型 A/A 在弥漫性皮肤 SSc (dcSSc) 中显着增加（dcSSc 中为 41.3%，对照组为 20.9%，P= 0.0018，比值比 = 2.67）。 IL10RB 5' 侧翼区域的 SNP rs999788 也显示与 dcSSc 相关；然而，这种关联被证明是由与 rs2834167 的连锁不平衡引起的。在有限的皮肤 SSc (1cSSc) 中未观察到显着关联。抗拓扑异构酶 I 抗体的存在也与 rs2834167A/A 基因型相关 (P=0.0019)。血清IL-10水平与rs2834167A等位基因数量显着相关(P=0.007)。这些发现表明，通过 IL-10R2 的信号传导可能在 dcSSc 中发挥致病作用。 (c) 2008 Elsevier Inc. 保留所有权利。
Interleukin-10 (IL-10) signaling has been suggested to play a role in systemic sclerosis (SSc). IL10RB codes for IL-10 receptor 2 (IL-10R2), a component shared in receptor complexes for IL-10, IL-22, IL-26 and interferon (IFN)-gamma. In this study, we examined association of IL10RB polymorphism with susceptibility to SSc. Genotype A/A at rs2834167 (47K/K) was significantly increased in diffuse cutaneous SSc (dcSSc) (41.3% in dcSSc, 20.9% in controls, P= 0.0018, odds ratio = 2.67). A SNP in the 5' flanking region of IL10RB, rs999788, also showed association with dcSSc; however, this association was shown to be secondarily caused by linkage disequilibrium with rs2834167. Significant association was not observed in limited cutaneous SSc (1cSSc). Presence of anti-topoisomerase I antibody was also associated with rs2834167A/A genotype (P=0.0019). Serum IL-10 level was significantly associated with the number of rs2834167A allele (P=0.007). These findings suggested that signaling through IL-10R2 may play a causative role in dcSSc. (c) 2008 Elsevier Inc. All rights reserved.