Attenuating anger and aggression with neuromodulation of the vmPFC: A simultaneous tDCS-fMRI study
Attenuating anger and aggression with neuromodulation of the vmPFC: A simultaneous tDCS-fMRI study
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DOI：
10.1016/j.cortex.2018.09.010
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发表时间：
2018-12-01
期刊：
影响因子：
3.6
通讯作者：
Hendler, Talma
中科院分区：
文献类型：
--
作者：
Gilam, Gadi;Abend, Rany;Hendler, Talma
在人际挑衅期间的愤怒爆发可能导致暴力，并在许多病理条件下普遍存在。在充满愤怒的最后通牒游戏（aiUG）中，不公平的金钱提议伴随着书面挑衅会引发愤怒。拒绝这些提议与攻击性有关，而接受则与愤怒调节有关。我们先前证明了腹内侧前额叶皮层（vmPFC）在接受不公平的报价和减弱愤怒的aiUG期间的参与，暗示其在愤怒调节中的作用。在这里，我们的目的是提高愤怒的调节，通过促进vmPFC活动在愤怒的诱导，使用阳极经颅直流电刺激（tDCS），同时与功能磁共振成像，以验证调制的vmPFC活动。在交叉、假手术对照、双盲研究中，参与者（N = 25）各自扫描两次，抵消在施用aiUG期间应用的假手术和活性tDCS。结果测量包括主动刺激与假刺激对vmPFC活动的影响，不公平的接受率，自我报告的愤怒，以及随后的反应性攻击范式中的攻击行为。结果表明，积极的刺激导致增加VMPFC活动过程中的不公平的报价，这些报价的接受率增加，并减轻增加自我报告的愤怒后的aiUG。我们还注意到，在主动刺激后，随后的攻击行为有所减少，但只有在第一次实验中进行主动刺激时。最后，一项探索性的发现表明，具有更强的习惯性倾向的参与者使用抑制作为情绪调节策略，与假刺激条件相比，在活动的aiUG之后报告了更少的愤怒。研究结果支持一个潜在的因果关系之间的联系VMPFC的功能和愤怒的经验和表达，支持VMPFC的愤怒调节的作用，并提供了一个有前途的途径，减少愤怒和侵略性的爆发在人际挑衅在各种精神和医疗条件。(C)2018爱思唯尔有限公司版权所有。
Angry outbursts during interpersonal provocations may lead to violence and prevails in numerous pathological conditions. In the anger-infused Ultimatum Game (aiUG), unfair monetary offers accompanied by written provocations induce anger. Rejection of such offers relates to aggression, whereas acceptance to anger regulation. We previously demonstrated the involvement of the ventro-medial prefrontal cortex (vmPFC) in accepting unfair offers and attenuating anger during an aiUG, suggestive of its role in anger regulation. Here, we aimed to enhance anger regulation by facilitating vmPFC activity during anger induction, using anodal transcranial direct current stimulation (tDCS) and simultaneously with functional Magnetic Resonance Imaging to validate modulation of vmPFC activity. In a cross-over, sham-controlled, double-blind study, participants (N = 25) were each scanned twice, counterbalancing sham and active tDCS applied during administration of the aiUG. Outcome measures included the effect of active versus sham stimulation on vmPFC activity, unfair offers' acceptance rates, self-reported anger, and aggressive behavior in a subsequent reactive aggression paradigm. Results indicate that active stimulation led to increased vmPFC activity during the processing of unfair offers, increased acceptance rates of these offers, and mitigated the increase in self-reported anger following the aiUG. We also noted a decrease in subsequent aggressive behavior following active stimulation, but only when active stimulation was conducted in the first experimental session. Finally, an exploratory finding indicated that participants with a stronger habitual tendency to use suppression as an emotion regulation strategy, reported less anger following the aiUG in the active compared to sham stimulation conditions. Findings support a potential causal link between vmPFC functionality and the experience and expression of anger, supporting vmPFC's role in anger regulation, and providing a promising avenue for reducing angry and aggressive outbursts during interpersonal provocations in various psychiatric and medical conditions. (C) 2018 Elsevier Ltd. All rights reserved.