Effect of Preexisting Serum and Mucosal Antibody on Experimental Respiratory Syncytial Virus (RSV) Challenge and Infection of Adults
Effect of Preexisting Serum and Mucosal Antibody on Experimental Respiratory Syncytial Virus (RSV) Challenge and Infection of Adults
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DOI：
10.1093/infdis/jiv281
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发表时间：
2015-12-01
影响因子：
6.4
通讯作者：
DeVincenzo, John P.
中科院分区：
文献类型：
--
作者：
Bagga, Bindiya;Cehelsky, Jeffrey E.;DeVincenzo, John P.
我们研究了预先存在的呼吸道合胞病毒（RSV）特异性血清和鼻腔抗体及其与人类实验感染模型中的感染性、病毒动力学和疾病严重程度的相关性。较高的接种前血清中和抗体滴度和鼻免疫球蛋白（IG）A预测较低的感染性和较低的病毒复制措施。然而，一旦个体被感染，先前存在的抗体没有明显的保护作用。观察到血清和粘膜抗体之间缺乏相关性，这意味着它们是针对RSV感染的保护的独立相关物。我们认为，RSV感染的保护是粘膜和血清体液免疫反应之间复杂相互作用的功能。
We studied preexisting respiratory syncytial virus (RSV)specific serum and nasal antibodies and their correlation with infectivity, viral dynamics, and disease severity in a human experimental infection model. Higher preinoculation serum neutralizing antibody titers and nasal immunoglobulin (Ig) A predicted lower infectivity and lower measures of viral replication. However, once individuals were infected, no significant protective effect of preexisting antibodies was seen. Lack of correlation between serum and mucosal antibodies was observed, implying that they are independent co-correlates of protection against RSV infection. We suggest that protection from RSV infection is a function of a complex interplay between mucosal and serum humoral immune responses.