Pre-eclampsia
Pre-eclampsia
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DOI：
10.1007/978-3-030-16481-2_34
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
D. Carty
中科院分区：
文献类型：
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作者：
D. Carty
先兆子痫是妊娠多系统疾病，以高血压和蛋白尿为特征，发生在妊娠20周后。先兆子痫不仅与妊娠并发症有关，如早产和胎儿生长受限，现在越来越多的人知道它与晚年的心血管疾病有关。尽管对这种疾病进行了数十年的研究，但它仍然难以预测、难以诊断和难以治疗。在本章中，将讨论疾病的病理生理机制和起源，重点是胎盘和心血管因素。将讨论改善疾病早期预测和治疗策略的潜在标志物，以及先兆子痫与未来孕产妇健康问题之间的关系。
Pre-eclampsia is a multisystem disorder of pregnancy, characterised by hypertension and proteinuria, occurring after 20 weeks of gestation. As well as being associated with pregnancy complications such as preterm delivery and foetal growth restriction, pre-eclampsia is now increasingly known to be associated with cardiovascular diseases in later life. Despite decades of research into the condition, it remains difficult to predict, difficult to diagnose and difficult to treat.In this chapter pathophysiological mechanisms and origins of disease will be discussed, with a focus on placental and cardiovascular factors. Potential markers to improve early prediction of disease and therapeutic strategies will be discussed, as well as the relationship between pre-eclampsia and future maternal health problems.