Electrodeposition of hydroxyapatite coating on Mg-4.0Zn-1.0Ca-0.6Zr alloy and in vitro evaluation of degradation, hemolysis, and cytotoxicity
Electrodeposition of hydroxyapatite coating on Mg-4.0Zn-1.0Ca-0.6Zr alloy and in vitro evaluation of degradation, hemolysis, and cytotoxicity
复制标题
Mg-4.0Zn-1.0Ca-0.6Zr合金上羟基磷灰石涂层的电沉积及其降解、溶血和细胞毒性的体外评价
DOI：
10.1002/jbm.a.34042
复制
发表时间：
2012-04-01
影响因子：
4.9
通讯作者：
Liu, Huinan
中科院分区：
文献类型：
--
作者：
Guan, Ren-Guo;Johnson, Ian;Liu, Huinan
采用熔炼、铸造、轧制和热处理等一系列冶金工艺成功制备了一种新型的可生物降解Mg-4.0Zn-1.0Ca-0.6Zr（wt %）合金。经轧制和175 ℃时效12 h后，合金板材的硬度和抗拉强度分别达到71.2HV和320 MPa。这些力学性能足以用于承重骨科植入物。采用碱热预处理、电沉积和碱热后处理相结合的新工艺，在Mg-4.0Zn-1.0Ca-0.6Zr（wt %）合金表面制备了羟基磷灰石（HA）涂层。采用扫描电子显微镜（SEM）、X射线能谱仪（EDS）和X射线衍射仪（XRD）对Mg-4.0Zn-1.0Ca-0.6Zr（wt %）合金和HA涂层的显微组织、成分和物相进行了表征。研究了HA涂层和未涂层Mg-4.0Zn-1.0Ca-0.6Zr（wt %）合金的体外降解、溶血和细胞相容性。Mg-4.0Zn-1.0Ca-0.6Zr合金的腐蚀电位（Ecorr）（-1.72 V）高于Mg（-1.95 V）、Mg-0.6Ca合金（-1.91 V）和Mg-1.0Ca合金（-1.97 V），表明Mg-Zn-Ca-Zr合金具有更好的耐蚀性。HA涂覆的镁合金样品的初始腐蚀电位（-1.51V）高于未涂覆的样品（-1.72V）。HA涂层和未涂层Mg-4.0Zn-1.0Ca-0.6Zr（wt %）合金样品的溶血率均为
A novel biodegradable Mg-4.0Zn-1.0Ca-0.6Zr (wt %) alloy was successfully produced using a series of metallurgical processes; including melting, casting, rolling, and heat treatment. The hardness and ultimate tensile strength of the alloy sheets increased to 71.2HV and 320 MPa after rolling and then aging for 12 h at 175 degrees C. These mechanical properties were sufficient for load-bearing orthopedic implants. A hydroxyapatite (HA) coating was deposited on the Mg-4.0Zn-1.0Ca-0.6Zr (wt %) alloy using a novel coating process combining alkali heat pretreatment, electrodeposition, and alkali heat posttreatment. The microstructure, composition, and phases of the Mg-4.0Zn-1.0Ca-0.6Zr (wt %) alloy and HA coating were characterized using scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), and X-ray diffraction (XRD). The degradation, hemolysis, and cytocompatibility of the HA-coated and uncoated Mg-4.0Zn-1.0Ca-0.6Zr (wt %) alloy were studied in vitro. The corrosion potential (Ecorr) of Mg-4.0Zn-1.0Ca-0.6Zr alloy (-1.72 V) was higher than Mg (-1.95 V), Mg-0.6Ca alloy (-1.91 V) and Mg-1.0Ca alloy (-1.97 V), indicating the Mg-Zn-Ca-Zr alloy would be more corrosion resistant. The initial corrosion potential of the HA-coated Mg alloy sample (-1.51 V) was higher than the uncoated sample (-1.72 V). The hemolysis rates of the HA-coated and uncoated Mg-4.0Zn-1.0Ca-0.6Zr (wt %) alloy samples were both