AGE-RELATED-CHANGES OF EXPRESSION OF IL-2 RECEPTOR SUBUNITS AND KINETICS OF IL-2 INTERNALIZATION IN T-CELLS AFTER MITOGENIC STIMULATION
AGE-RELATED-CHANGES OF EXPRESSION OF IL-2 RECEPTOR SUBUNITS AND KINETICS OF IL-2 INTERNALIZATION IN T-CELLS AFTER MITOGENIC STIMULATION
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DOI：
10.1016/0047-6374(88)90106-6
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发表时间：
1988-11-14
影响因子：
5.3
通讯作者：
KISHIMOTO, S
中科院分区：
文献类型：
--
作者：
HARA, H;TANAKA, T;KISHIMOTO, S
The age-associated changes of the expression of IL-2 binding molecules p55/Tac(.alpha. chain) and p70/75(.beta. chain) were examined after phytohemagglutinin (PHA) stimulation. The expression of both p55/Tac molecules and p70/75 molecules were significantly reduced in the aged compared with those in the young persons. The amounts of p55/Tac and p70/75 molecules on T cells from the aged were 55% and 59% of those on young ones, respectively. The ratio of the amount of p70/75 to that of p55/Tac in aged T cells was 0.28 and that in young ones was 0.26. The ratio was somewhat higher in the aged but not significantly. We also examined the kinetics of IL-2 internalization mediated by its receptor. The calculated t1/2 of receptor-mediated IL-2 internalization was 17 min in the aged and 16 min in the young, respectively. There was no kinetic difference between the 2 groups. The percentage of the internalized IL-2 to the sum total was 58.2% in the aged and 73.4% in the young (P < 0.02). The amount of internalized IL-2 in T cells from the aged was 48.6% of that from the young (P < 0.01).
