Non-contact biomedical photoacoustic and ultrasound imaging
Non-contact biomedical photoacoustic and ultrasound imaging
复制标题
DOI：
10.1117/1.jbo.17.6.061217
复制
发表时间：
2012-06-01
影响因子：
3.5
通讯作者：
Monchalin, Jean-Pierre
中科院分区：
文献类型：
--
作者：
Rousseau, Guy;Gauthier, Bruno;Monchalin, Jean-Pierre
光声层析成像（PAT）中的超声检测通常依赖于通过耦合介质与生物组织接触的超声换能器。这对于重要的潜在应用如外科手术是一个主要缺点。在这里，我们报告使用的远程光学方法，来自工业激光超声，检测组织中的超声。这种方法可以实现非接触式PAT（NCPAT），而不会超过激光暴露安全限值。该方法的灵敏度是基于使用适当形状的检测激光脉冲和共焦法布里-珀罗干涉仪在差分配置。利用光学相干层析成像系统对组织的表面轮廓进行远程测量，可获得可靠的图像重建。所提出的方法还允许通过将第二重建算法应用于针对NCPAT采集的数据来进行非接触式超声成像（US）。内源性和外源性夹杂物表现出光学和声学对比检测离体鸡胸肉和小牛脑标本。在超过1厘米的深度处检测到尺寸小至0.3毫米的夹杂物。该方法可以将光声和US的范围扩展到接触不切实际的体内生物医学应用。(C)2012年，美国光电仪器工程师学会（SPIE）。[DOI：10.1117/1.JBO.17.6.061217]
The detection of ultrasound in photoacoustic tomography (PAT) usually relies on ultrasonic transducers in contact with the biological tissue through a coupling medium. This is a major drawback for important potential applications such as surgery. Here we report the use of a remote optical method, derived from industrial laser-ultrasonics, to detect ultrasound in tissues. This approach enables non-contact PAT (NCPAT) without exceeding laser exposure safety limits. The sensitivity of the method is based on the use of suitably shaped detection laser pulses and a confocal Fabry-Perot interferometer in differential configuration. Reliable image reconstruction is obtained by measuring remotely the surface profile of the tissue with an optical coherence tomography system. The proposed method also allows non-contact ultrasound imaging (US) by applying a second reconstruction algorithm to the data acquired for NCPAT. Endogenous and exogenous inclusions exhibiting optical and acoustic contrasts were detected ex vivo in chicken breast and calf brain specimens. Inclusions down to 0.3 mm in size were detected at depths exceeding 1 cm. The method could expand the scope of photoacoustic and US to in-vivo biomedical applications where contact is impractical. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.6.061217]