Self-assembled rosette nanotubes encapsulate and slowly release dexamethasone
Self-assembled rosette nanotubes encapsulate and slowly release dexamethasone
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DOI：
10.2147/ijn.s18755
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发表时间：
2011-01-01
影响因子：
8
通讯作者：
Webster, Thomas J.
中科院分区：
文献类型：
--
作者：
Chen, Yupeng;Song, Shang;Webster, Thomas J.
玫瑰花状纳米管（RNT）是一种新型的、自组装的、仿生的、合成的药物递送材料，适用于许多医学应用。由于其两亲性和中空结构，RNT可用于封装和递送疏水药物，否则难以在生物系统中递送。使用RNT用于药物递送的另一个优点是它们的生物相容性、低细胞毒性以及它们产生有利的、生物启发的环境以用于细胞粘附和生长的能力。在这项研究中，开发了一种将地塞米松（DEX，一种炎症和骨生长促进类固醇）掺入RNT的方法。使用扩散有序核磁共振光谱（DOSY NMR）和紫外可见光谱对载药RNT进行表征。结果首次表明，DEX可以轻松快速地封装到RNT中，并在长时间内释放以促进成骨细胞（骨形成细胞）的功能。因此，RNTs被认为是一种新的材料，用于靶向递送疏水药物，否则难以递送。
Rosette nanotubes (RNTs) are novel, self-assembled, biomimetic, synthetic drug delivery materials suitable for numerous medical applications. Because of their amphiphilic character and hollow architecture, RNTs can be used to encapsulate and deliver hydrophobic drugs otherwise difficult to deliver in biological systems. Another advantage of using RNTs for drug delivery is their biocompatibility, low cytotoxicity, and their ability to engender a favorable, biologically-inspired environment for cell adhesion and growth. In this study, a method to incorporate dexamethasone (DEX, an inflammatory and a bone growth promoting steroid) into RNTs was developed. The drug-loaded RNTs were characterized using diffusion ordered nuclear magnetic resonance spectroscopy (DOSY NMR) and UV-Vis spectroscopy. Results showed for the first time that DEX can be easily and quickly encapsulated into RNTs and released to promote osteoblast (bone-forming cell) functions over long periods of time. As a result, RNTs are presented as a novel material for the targeted delivery of hydrophobic drugs otherwise difficult to deliver.