Causes of Acute Hospitalization in Adolescence: Burden and Spectrum of HIV-Related Morbidity in a Country with an Early-Onset and Severe HIV Epidemic: A Prospective Survey
Causes of Acute Hospitalization in Adolescence: Burden and Spectrum of HIV-Related Morbidity in a Country with an Early-Onset and Severe HIV Epidemic: A Prospective Survey
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DOI：
10.1371/journal.pmed.1000178
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发表时间：
2010-02-01
期刊：
影响因子：
15.8
通讯作者：
Corbett, Elizabeth L.
中科院分区：
文献类型：
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作者：
Ferrand, Rashida A.;Bandason, Tsitsi;Corbett, Elizabeth L.
背景资料：未经治疗的纵向获得性艾滋病毒感染者存活到较大的儿童期，这在以前被认为是极不寻常的，现在越来越多地得到了很好的描述。然而，青少年健康的整体影响，在设置高艾滋病毒血清阳性率以前没有investigated.Methods和调查结果：青少年（年龄10-18岁）系统招募急性入院的两个公立医院在哈拉雷，津巴布韦，回答了问卷，并进行了标准的调查，包括艾滋病毒检测，同意。预先设定的病例定义定义了入院原因和基础慢性疾病。参与率为94%。301名参与者中有139名（46%）为HIV阳性（诊断的中位年龄12岁：四分位距[IQR] 11-14岁），中位CD 4计数= 151; IQR 57-328个细胞/μ l），但只有4名（1.3%）为单纯疱疹病毒-2（HSV-2）阳性。年龄（中位数13岁）：IQR 11-16岁）和性别（57%男性）没有因HIV状态而存在差异，但HIV感染者明显更有可能发育迟缓（z评分< -2：52%对23%，p
Background: Survival to older childhood with untreated, vertically acquired HIV infection, which was previously considered extremely unusual, is increasingly well described. However, the overall impact on adolescent health in settings with high HIV seroprevalence has not previously been investigated.Methods and Findings: Adolescents (aged 10-18 y) systematically recruited from acute admissions to the two public hospitals in Harare, Zimbabwe, answered a questionnaire and underwent standard investigations including HIV testing, with consent. Pre-set case-definitions defined cause of admission and underlying chronic conditions. Participation was 94%. 139 (46%) of 301 participants were HIV-positive (median age of diagnosis 12 y: interquartile range [IQR] 11-14 y), median CD4 count = 151; IQR 57-328 cells/mu l), but only four (1.3%) were herpes simplex virus-2 (HSV-2) positive. Age (median 13 y: IQR 11-16 y) and sex (57% male) did not differ by HIV status, but HIV-infected participants were significantly more likely to be stunted (z-score < -2: 52% versus 23%, p