[Importance of urinary 3-O methyldopamine in the metabolism of adrenergic tumors].
[Importance of urinary 3-O methyldopamine in the metabolism of adrenergic tumors].
复制标题
[尿3-O甲基多巴胺在肾上腺素能肿瘤代谢中的重要性]。
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
L. Peyrin
中科院分区：
文献类型：
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作者：
Y. Dalmaz;L. Peyrin
尿中 3-O 甲基多巴胺在所有恶性肿瘤以及交感性肿瘤（交感母细胞瘤）和嗜铬细胞瘤（嗜铬细胞瘤）中均显着升高，但在良性交感神经肿瘤（神经节神经瘤）中升高程度较低。另一方面，3-O 甲基多巴胺排泄在良性嗜铬细胞瘤中是正常的。该化合物在多巴胺能阻滞中的比例在交感母细胞瘤中增加，在神经节神经元中减少，在嗜铬细胞瘤中不变。尚未对恶性嗜铬细胞瘤病例进行此类分析。整个多巴胺能和去甲肾上腺素能代谢中 3-O 甲基多巴胺的比例仅在交感母细胞瘤中增加。在其他情况下（神经节神经瘤和嗜铬细胞瘤），该比率会降低。对尿液中 3-O 甲基多巴胺和其他两种甲氧基化胺（去甲肾上腺素和变肾上腺素）的比较分析表明，与正常受试者的值相比，多巴胺的甲氧基化衍生物在交感母细胞瘤中增加程度最大，而在神经节神经元和嗜铬细胞肿瘤中，去甲变肾上腺素在不同程度上是主要化合物。
Urinary 3-O methyldopamine has been found highly increased in all cases of malignant tumours, as well of sympathetic nature (sympathoblastoma) as of chromaffin type (pheochromocytoma) but at a lesser extent in benign sympathetic tumours (ganglioneuroma). On the other hand, 3-O methyldopamine excretion is normal in benign pheochromocytoma. The ratio of this compound in the dopaminergic block is increased in sympathoblastoma, decreased in ganglioneurona and unchanged in pheochromocytoma. This kind of analysis has not been made for the case of malignant pheochromoblastoma. This ratio of 3-O methyldopamine in the whole dopaminergic and noradrenergic metabolism is increased only in sympathoblastoma. In the other cases (ganglioneuroma and pheochromocytoma) this ratio is decreased. Comparative analysis of urinary 3-O methyldopamine and the two other methoxylated amines (norepinephrine and metanephrine) shows that the methoxylated derivative of dopamine, when compared to normal subjects values, increased at the greatest extent in sympathoblastoma, while in ganglioneurona and chromaffin tumours, normetanephrine is with a variable degree, the predominant compound.