Reconsolidation and extinction: Using epigenetic signatures to challenge conventional wisdom.
Reconsolidation and extinction: Using epigenetic signatures to challenge conventional wisdom.
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DOI：
10.1016/j.nlm.2017.01.007
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发表时间：
2017-07
影响因子：
2.7
通讯作者：
Wood MA
中科院分区：
文献类型：
--
作者：
Hemstedt TJ;Lattal KM;Wood MA
表观遗传机制有可能引起细胞功能的持久变化，最终可以持久地影响行为。这个概念在恐惧再巩固和恐惧记忆消失方面特别有趣。这两种行为方法在实验室中被用来研究恐惧记忆是如何减弱的，这在寻找治疗焦虑症和创伤后应激障碍的治疗干预时变得很重要。在这里，我们回顾了几个关键的表观遗传机制在习得性恐惧的重新巩固和消除中的作用，以及它们对条件提示持续改变行为反应的潜力。我们还简要讨论了表观遗传机制如何建立持久性行为，挑战我们对灭绝和再巩固的定义。
Epigenetic mechanisms have the potential to give rise to lasting changes in cell function that ultimately can affect behavior persistently. This concept is especially interesting with respect to fear reconsolidation and fear memory extinction. These two behavioral approaches are used in the laboratory to investigate how fear memory can be attenuated, which becomes important when searching for therapeutic intervention to treat anxiety disorders and post-traumatic stress disorder. Here we review the role of several key epigenetic mechanisms in reconsolidation and extinction of learned fear and their potential to persistently alter behavioral responses to conditioned cues. We also briefly discuss how epigenetic mechanisms may establish persistent behaviors that challenge our definitions of extinction and reconsolidation.