Alendronate Increases Bone Density and Bone Strength at the Distal Radius in Postmenopausal Women
Alendronate Increases Bone Density and Bone Strength at the Distal Radius in Postmenopausal Women
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阿仑膦酸钠可增加绝经后女性桡骨远端的骨密度和骨强度
DOI：
10.1359/jbmr.1999.14.8.1387
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发表时间：
1999
影响因子：
6.2
通讯作者：
Joachim R. Ittner
中科院分区：
文献类型：
--
作者：
P. Schneider;M. Fischer;B. Allolio;D. Felsenberg;Ulf Schröder;J. Semler;Joachim R. Ittner
除了 1908 名入组患者的阿仑膦酸钠骨质疏松症干预试验 (FOSIT) 核心方案 901-0A 之外，还探索了使用外周定量计算机断层扫描 (pQCT) 来评估治疗反应。在多中心核心研究的一个子集中探讨了远端桡骨两个不同部位的骨矿物质和强度相关参数。 103 名患者参与了这项亚研究，并每天服用 10 毫克阿仑膦酸钠或安慰剂，为期 1 年。在第 0、3、6 和 12 个月进行测量。纳入标准是腰椎骨矿物质密度 (BMD) 测量结果为 -2 SD。通过腰椎和髋部的双能 X 射线吸收测定法以及桡骨超远端和轴部位的 pQCT 评估治疗反应。与 FOSIT 核心研究一致，阿仑膦酸钠增加了腰椎和髋部的 BMD，并降低了骨转换的血清生化标志物。该亚组研究显示，治疗组和安慰剂组之间由于治疗而在超远端部位的骨小梁密度（8.4%，p = 0.095）、总密度（6.8%，p = 0.009）和骨强度指数（BSI）（15.6 mm3，p = 0.037）方面存在差异，而桡骨轴没有变化。在治疗组中观察到腰椎 BMD 相对于基线的百分比变化与桡骨超远端部位的总密度和骨强度之间存在显着相关性，但在安慰剂组中则不然。因此，桡骨超远端部位确实对阿仑膦酸钠治疗有反应。骨密度的增加伴随着超远端部位 BSI 的显着增加，这一发现可能有助于解释阿仑膦酸钠骨折干预试验中腕部骨折的减少。
In addition to the alendronate Osteoporosis Intervention Trial (FOSIT) core protocol 901–0A of 1908 enrolled patients, the use of peripheral quantitative computed tomography (pQCT) was explored for the assessment of response to therapy. Bone mineral and strength related parameters at two different sites at the distal radius were explored in a subset of the multicenter core study. One hundred and three patients were entered into the substudy and given either a daily dose of 10 mg of alendronate or placebo for 1 year. Measurements were done at months 0, 3, 6, and 12. Inclusion criteria were bone mineral density (BMD) measurements at the lumbar spine of −2 SD. The response to therapy was assessed by dual‐energy X‐ray absorptiometry in the lumbar spine and the hip, and by pQCT in the ultradistal and the shaft sites of the radius. In line with the FOSIT core study, alendronate increased BMD at the lumbar spine and the hip, and it decreased the serum biochemical markers of bone turnover. The substudy showed differences between the therapy and placebo group in trabecular bone density (8.4%, p = 0.095), in total density (6.8%, p = 0.009), and in the bone strength index (BSI) (15.6 mm3, p = 0.037) at the ultradistal site due to treatment and no changes at the radius shaft. A significant correlation was observed between percentage changes from baseline in BMD of the lumbar spine, and in total density and bone strength at the ultradistal radius site in the treatment group, but not in the placebo group. Thus, the ultradistal radius site did respond to alendronate therapy. The increased bone density accompanied a significant gain in the BSI at the ultradistal site, a finding that might help explain the reduced wrist fractures in the alendronate Fracture Intervention Trial.
周围骨密度与轴向骨密度的关系。
DOI：
--
发表时间：
1988
期刊：
Bone and mineral
影响因子：
--
作者：
Schneider,P;Börner,W;Mazess,RB;Barden,H
通讯作者：
Barden,H