Ambiguous value of Haemophilus influenzae isolation in Guillain-Barre and Fisher syndromes
Ambiguous value of Haemophilus influenzae isolation in Guillain-Barre and Fisher syndromes
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DOI：
10.1136/jnnp.2005.065359
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发表时间：
2005-12-01
影响因子：
11
通讯作者：
Yuki, N
中科院分区：
文献类型：
--
作者：
Koga, M;Koike, S;Yuki, N
背景资料：流感嗜血杆菌被认为是格林-巴利综合征（GBS）和费舍尔综合征的病原体，但这种感染在GBS的频率是有争议的。目的：以确定是否分离流感嗜血杆菌表明它是一个病原体在GBS和费舍尔syndrome.Results：4（15%）的27例GBS和费舍尔综合征中，其中分离的流感嗜血杆菌也是空肠弯曲菌血清学阳性。抗神经节苷脂IgG抗体在这四名患者没有交叉反应，他们的流感嗜血杆菌脂寡糖，而抗神经节苷脂抗体在4例血清学阳性的流感嗜血杆菌does.Conclusions：研究结果表明，流感嗜血杆菌的分离并不总是指示在这些综合征的病原体和其他感染的测试，即使在阳性培养的情况下。
Background: Haemophilus influenzae is considered a causative agent of Guillain-Barre syndrome (GBS) and Fisher syndrome, but the frequency of this infection in GBS is controversial.Objective: To determine whether isolation of H influenzae indicates it is a causative agent in GBS and Fisher syndrome.Results: Four (15%) of 27 patients with GBS and Fisher syndrome in whom H influenzae was isolated were also seropositive for Campylobacter jejuni. Antiganglioside IgG antibodies in these four patients did not cross react with their H influenzae lipo-oligosaccharides, whereas antiganglioside antibodies in the four patients with positive serology for H influenzae did.Conclusions: The findings suggest that H influenzae isolation is not always indicative of the causative agent in these syndromes and that tests for other infections should be made, even in cases of positive culture.