Serine-threonine protein phosphatases: Lost in translation.

Serine-threonine protein phosphatases: Lost in translation.
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DOI:
10.1016/j.bbamcr.2018.08.006
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发表时间:
2019-01
期刊:
Biochimica et biophysica acta. Molecular cell research
影响因子:
--
通讯作者:
Kolupaeva V
Kolupaeva V
中科院分区:
其他
文献类型:
--
作者:
Kolupaeva V

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Protein synthesis is one of the most complex and energy-consuming processes in eukaryotic cells and therefore is tightly regulated. One of the main mechanisms of translational control is post-translational modifications of the components of translational apparatus. Phosphorylation status of translation factors depends on the balanced action of kinases and phosphatases. While many kinase-dependent events are well defined, phosphatases that counteract phosphorylation are rarely determined. This mini-review focuses on the regulation of activity of translational initiation factors by Serine/Threonine phosphatases.
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