Load-dependent functional connectivity deficits during visual working memory in first-episode psychosis.
Load-dependent functional connectivity deficits during visual working memory in first-episode psychosis.
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DOI：
10.1016/j.jpsychires.2022.06.042
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发表时间：
2022-09
影响因子：
4.8
通讯作者：
Salisbury, Dean F.
中科院分区：
文献类型：
--
作者：
Sklar, Alfredo L.;Coffman, Brian A.;Longenecker, Julia M.;Curtis, Mark;Salisbury, Dean F.
关键词：
异常网络连接是精神分裂症的核心缺陷，可能是许多相关认知缺陷的基础。先前在首发精神分裂症谱系疾病（FESz）中的工作表明，在低负荷条件下，随着任务复杂性的增加，工作记忆网络功能会出现功能障碍。本研究评估了视觉网络连接及其对负荷依赖性工作记忆障碍的贡献。脑磁图记录从35 FESz和28匹配的控制（HC）在偏侧变化检测任务。先前在双侧枕背（Occ）区域内发现α去钙化受损。在这里，使用锁相（PLV）和双边OCC作为连接种子检查全脑α带连接。在参与者中评估了负载对连接的影响，并在各组之间比较了网络内的PLV调制。OCC表现出显着的负载调制连接与六个地区（FDR校正）。HC表现出PLV增强与负载在所有连接。FESz未能显示右侧Occ和左侧额下回、外侧枕颞沟和前中间顶叶沟之间的PLV调制。在两种记忆负荷条件下，所有三个网络连接中较小的PLV与FESz中增加的现实失真（FDR校正）相关。在FESz的视觉工作记忆网络的功能连接的检查显示，无法增强感知和执行网络之间的通信，以响应不断增加的认知需求。此外，网络沟通障碍的程度与阳性症状相关。这些发现提供了对大脑连接障碍的性质及其对早期精神病症状的贡献的见解，并确定了未来干预的潜在目标。
Aberrant network connectivity is a core deficit in schizophrenia and may underlie many of its associated cognitive deficits. Previous work in first-episode schizophrenia spectrum illness (FESz) suggests preservation of working memory network function during low-load conditions with dysfunction emerging as task complexity increases. This study assessed visual network connectivity and its contribution to load-dependent working memory impairments. Magnetoencephalography was recorded from 35 FESz and 28 matched controls (HC) during a lateralized change detection task. Impaired alpha desynchronization was previously identified within bilateral dorsal occipital (Occ) regions. Here, whole-brain alpha-band connectivity was examined using phase-locking (PLV) and bilateral Occ as connectivity seeds. Load effects on connectivity were assessed across participants, and PLV modulation within networks was compared between groups. Occ exhibited significant load modulated connectivity with six regions (FDR-corrected). HC exhibited PLV enhancement with load in all connections. FESz failed to show PLV modulation between right Occ and left inferior frontal gyrus, lateral occipito-temporal sulcus, and anterior intermediate parietal sulcus. Smaller PLVs in all three network connections during both memory load conditions were associated with increased reality distortion in FESz (FDR-corrected.) Examination of functional connectivity across the visual working memory network in FESz revealed an inability to enhance communication between perceptual and executive networks in response to increasing cognitive demands. Furthermore, the degree of network communication impairment was associated with positive symptoms. These findings provide insights into the nature of brain dysconnectivity and its contribution to symptoms in early psychosis and identify potential targets for future interventions.
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影响因子：
4.6
作者：
Luck, Steven J.;McClenon, Clara;Gold, James M.
通讯作者：
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影响因子：
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作者：
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DOI：
10.3758/s13415-020-00823-3
发表时间：
2020-10
期刊：
Cognitive, affective & behavioral neuroscience
影响因子：
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作者：
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