EFFECTS OF FAT MASS REDUCTION BY DIETING AND BY LIPECTOMY ON CARBOHYDRATE-METABOLISM IN OBESE PATIENTS
EFFECTS OF FAT MASS REDUCTION BY DIETING AND BY LIPECTOMY ON CARBOHYDRATE-METABOLISM IN OBESE PATIENTS
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DOI：
10.1007/bf02581094
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发表时间：
1979-01-01
期刊：
影响因子：
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通讯作者：
CREPALDI, G
中科院分区：
文献类型：
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作者：
ENZI, G;CAGNONI, G;CREPALDI, G
研究了肥胖症合并化学性糖尿病患者体脂质量增加(BFM)与碳水化合物耐量降低和高胰岛素血症的关系。这些患者在低卡路里、低碳水化合物饮食导致体重减轻后接受了脂肪切除术。在饮食诱导的BFM下降9.9+-后，观察到葡萄糖耐量和胰岛素敏感性的改善，以及在OGTT[口服葡萄糖耐量试验]期间胰岛素释放的减少。1.2千克。随后的手术使BFM减少了6.0+-。0.5 kg对碳水化合物耐量、胰岛素释放或胰岛素敏感性没有进一步的影响，但观察到基础血浆FFA[游离脂肪酸]值显著下降。脂肪体积增大本身并不影响口服或静脉注射后的血糖稳态。正在装车。饮食诱导的BFM丢失后，通常可以观察到的碳水化合物耐量和胰岛素抵抗的改善似乎是由于热量和碳水化合物摄入量的减少，而不是BFM的减少。
The interrelation of enlarged body fat mass (BFM) with reduced carbohydrate tolerance and hyperinsulinemia was studied in obese subjects with chemical diabetes. These patients were subjected to lipectomy following weight loss induced by a low-calorie, low-carbohydrate diet. An improvement in glucose tolerance and in insulin sensitivity and a reduction in insulin release during OGTT [oral glucose tolerance test] was observed after a diet-induced BFM loss of 9.9 .+-. 1.2 kg. Subsequent surgical reduction of BFM by 6.0 .+-. 0.5 kg had no further effect on carbohydrate tolerance, insulin release or insulin sensitivity, although a marked decrease in basal plasma FFA [free fatty acid] values was observed. Fat mass enlargement per se has no effect on blood glucose homeostasis after oral or i.v. loading. The improvement in carbohydrate tolerance and in insulin resistance usually observed following diet-induced loss of BFM seems to be due to the reduction in calorie and carbohydrate intake rather than to decrease of BFM.