Mechanisms of Schwann cell plasticity involved in peripheral nerve repair after injury.
Mechanisms of Schwann cell plasticity involved in peripheral nerve repair after injury.
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DOI：
10.1007/s00018-020-03516-9
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Jacob C
中科院分区：
文献类型：
--
作者：
Nocera G;Jacob C
雪旺细胞（Schwann cells，SC）是周围神经系统（PNS）的髓鞘化胶质细胞，其可塑性强，是创伤性损伤和周围神经病后周围神经再生的重要特征。神经损伤后，SC被损伤诱导的信号迅速激活，并通过进入修复程序作出反应。在修复过程中，SC经历动态细胞重编程和形态发生变化，旨在促进神经再生和功能恢复。SC转化为修复表型，激活髓鞘形成的负调节因子并使受损神经脱髓鞘。此外，它们表达许多典型的未成熟状态的基因以及许多从头基因。这些基因通过促进神经元存活、受损轴突崩解、髓鞘清除、轴突再生和引导其前靶点，以及通过最终使再生轴突髓鞘再生来调节和驱动再生过程。许多信号通路、转录调节因子和表观遗传机制调节这些事件。在这篇综述中，我们讨论了修复程序的主要步骤，特别关注调节周围神经损伤后SC可塑性的分子机制。
The great plasticity of Schwann cells (SCs), the myelinating glia of the peripheral nervous system (PNS), is a critical feature in the context of peripheral nerve regeneration following traumatic injuries and peripheral neuropathies. After a nerve damage, SCs are rapidly activated by injury-induced signals and respond by entering the repair program. During the repair program, SCs undergo dynamic cell reprogramming and morphogenic changes aimed at promoting nerve regeneration and functional recovery. SCs convert into a repair phenotype, activate negative regulators of myelination and demyelinate the damaged nerve. Moreover, they express many genes typical of their immature state as well as numerous de-novo genes. These genes modulate and drive the regeneration process by promoting neuronal survival, damaged axon disintegration, myelin clearance, axonal regrowth and guidance to their former target, and by finally remyelinating the regenerated axon. Many signaling pathways, transcriptional regulators and epigenetic mechanisms regulate these events. In this review, we discuss the main steps of the repair program with a particular focus on the molecular mechanisms that regulate SC plasticity following peripheral nerve injury.
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影响因子：
16.2
作者：
Brinkmann, Bastian G.;Agarwal, Amit;Sereda, Michael W.;Garratt, Alistair N.;Mueller, Thomas;Wende, Hagen;Stassart, Ruth M.;Nawaz, Schanila;Humml, Christian;Velanac, Viktorija;Radyushkin, Konstantin;Goebbels, Sandra;Fischer, Tobias M.;Franklin, Robin J.;Lai, Cary;Ehrenreich, Hannelore;Birchmeier, Carmen;Schwab, Markus H.;Nave, Klaus Armin
通讯作者：
Nave, Klaus Armin
DOI：
10.1523/jneurosci.3481-16.2017
发表时间：
2017-04-19
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Benito C;Davis CM;Gomez-Sanchez JA;Turmaine M;Meijer D;Poli V;Mirsky R;Jessen KR
通讯作者：
Jessen KR
影响因子：
3.5
作者：
Baron, W;Metz, B;de Vries, H
通讯作者：
de Vries, H
影响因子：
14.5
作者：
Antonio Gomez-Sanchez, Jose;Gomis-Coloma, Clara;Cabedo, Hugo
通讯作者：
Cabedo, Hugo
影响因子：
5.3
作者：
Chen, S;Velardez, MO;Corfas, G
通讯作者：
Corfas, G