The Oncopig as an Emerging Model to Investigate Copper Regulation in Cancer.
The Oncopig as an Emerging Model to Investigate Copper Regulation in Cancer.
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DOI：
10.3390/ijms232214012
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发表时间：
2022-11-13
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
新出现的证据表明，铜 (Cu) 对促进癌症等人类疾病的发展有几个基本贡献。最近对铜在癌症生物学中的作用的越来越多的认识凸显了开发新的抗癌策略的一个有前景的领域。 Cu 及其调节蛋白网络参与癌症的许多不同背景方面，从驱动细胞信号传导、调节细胞周期进程、建立上皮-间质转化以及促进肿瘤生长和转移。一般来说，人类癌症研究需要完善的模型来弥合基础科学研究和有意义的临床试验之间的差距。由于固有的遗传和生理差异，对培养的癌细胞系和动物模型（例如小鼠和大鼠）的经典研究在扩展到人类时经常会出现警告。然而，猪等大型动物模型正在成为更合适的转化研究工具，因为它们在遗传学、解剖结构、器官大小和癌症等疾病的病理表现方面与人类有更多相似之处。这些相似之处使得猪模型非常适合解决癌症生物学以及针对人类癌症的新药和治疗开发领域中长期存在的问题。随着铜在人类健康和病理学中的新兴作用，猪提供了一个新兴且有价值的模型来进一步研究这种金属对人类癌症的贡献。 Oncopig 癌症模型是一种转基因猪模型，通过位点和细胞特异性肿瘤的发育来概括人类癌症。在这篇综述中，我们简要概述了铜与癌症之间的关系，以及如何使用新型 Oncopig 癌症模型来更好地理解铜与癌症相关分子靶点之间的机制和因果关系。
Emerging evidence points to several fundamental contributions that copper (Cu) has to promote the development of human pathologies such as cancer. These recent and increasing identification of the roles of Cu in cancer biology highlights a promising field in the development of novel strategies against cancer. Cu and its network of regulatory proteins are involved in many different contextual aspects of cancer from driving cell signaling, modulating cell cycle progression, establishing the epithelial-mesenchymal transition, and promoting tumor growth and metastasis. Human cancer research in general requires refined models to bridge the gap between basic science research and meaningful clinical trials. Classic studies in cultured cancer cell lines and animal models such as mice and rats often present caveats when extended to humans due to inherent genetic and physiological differences. However, larger animal models such as pigs are emerging as more appropriate tools for translational research as they present more similarities with humans in terms of genetics, anatomical structures, organ sizes, and pathological manifestations of diseases like cancer. These similarities make porcine models well-suited for addressing long standing questions in cancer biology as well as in the arena of novel drug and therapeutic development against human cancers. With the emergent roles of Cu in human health and pathology, the pig presents an emerging and valuable model to further investigate the contributions of this metal to human cancers. The Oncopig Cancer Model is a transgenic swine model that recapitulates human cancer through development of site and cell specific tumors. In this review, we briefly outline the relationship between Cu and cancer, and how the novel Oncopig Cancer Model may be used to provide a better understanding of the mechanisms and causal relationships between Cu and molecular targets involved in cancer.
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影响因子：
4.8
作者：
Casareno, RLB;Waggoner, D;Gitlin, JD
通讯作者：
Gitlin, JD
铜稳态的改变是肝细胞癌对铜螯合敏感性的基础。
DOI：
10.1039/d0mt00156b
发表时间：
2020-12-23
期刊：
Metallomics : integrated biometal science
影响因子：
--
作者：
Davis CI;Gu X;Kiefer RM;Ralle M;Gade TP;Brady DC
通讯作者：
Brady DC
影响因子：
11.2
作者：
Brady DC;Crowe MS;Greenberg DN;Counter CM
通讯作者：
Counter CM
影响因子：
3.6
作者：
Babich, Polina S.;Skvortsov, Alexey N.;Broggini, Massimo
通讯作者：
Broggini, Massimo
影响因子：
50.3
作者：
Erler JT;Bennewith KL;Cox TR;Lang G;Bird D;Koong A;Le QT;Giaccia AJ
通讯作者：
Giaccia AJ