"Indeterminate" microvolt T-wave alternans tests predict high risk of death or sustained ventricular arrhythmias in patients with left ventricular dysfunction
"Indeterminate" microvolt T-wave alternans tests predict high risk of death or sustained ventricular arrhythmias in patients with left ventricular dysfunction
复制标题
DOI：
10.1016/j.jacc.2006.06.044
复制
发表时间：
2006-10-03
影响因子：
24
通讯作者：
Bigger, J. Thomas
中科院分区：
文献类型：
--
作者：
Kaufman, Elizabeth S.;Bloomfield, Daniel M.;Bigger, J. Thomas
本研究测试了一个假设，即“不确定”微伏T波电交替（MTWA）测试，当由于异位，不持续的MTWA，或低运动心率（HR），具有类似于阳性MTWA test.Background MTWA测试，用于分层的风险突然或总死亡率的患者结构性心脏病，已被限制了大量的“不确定”测试的预后意义。不确定的测试是由于患者因素-运动期间过度的心室异位，不持续的MTWA，或未能达到HR 105次/分钟持续1分钟-或技术因素，如嘈杂的记录或运动方案，导致HR过快上升。
OBJECTIVES This study tested the hypothesis that an "indeterminate" microvolt T-wave alternans (MTWA) test, when due to ectopy, unsustained MTWA, or low exercise heart rate (HR), has prognostic significance similar to a positive MTWA test.BACKGROUND MTWA testing, used to stratify risk of sudden or total mortality in patients with structural heart disease, has been limited by a substantial number of "indeterminate" tests. Indeterminate tests are due to patient factors-excessive ventricular ectopy during exercise, unsustained MTWA, or failure to achieve a HR of 105 beats/min for 1 min-or technical factors such as a noisy recording or an exercise protocol that causes an excessively rapid rise in HR.METHODS Patients in sinus rhythm with left ventricular ejection fraction