Trichinella spiralis infection alters small bowel motor activity in the fed state.
Trichinella spiralis infection alters small bowel motor activity in the fed state.
复制标题
旋毛虫感染会改变进食状态下的小肠运动活动。
DOI：
10.1016/0016-5085(91)90523-n
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发表时间：
1991
期刊：
影响因子：
29.4
通讯作者：
Sarna,SK
中科院分区：
文献类型：
--
作者：
Cowles,VE;Sarna,SK
本文研究了旋毛虫感染对进食状态下小肠传输和运动活动的影响。用应变传感器记录收缩，用标记物稀释技术测量平均通过时间。旋毛虫病期间，个体阶段性收缩的平均幅度和面积减小，但其平均持续时间无变化。相位收缩的总振幅和面积也降低;这是由收缩频率降低以及平均参数降低引起的。总持续时间的减少完全是由频率的降低引起的。所有收缩的总参数的减少是传播和非传播收缩的相同参数减少的结果。然而，传播收缩参数的下降幅度要大得多。此外，有一个阶段性收缩的传播距离减少。T时相性收缩的传导时间增加。螺旋感染此外，T.在进食状态下，螺旋体感染诱导了巨大的迁移性收缩，而在对照组中从未观察到。巨大的迁移收缩使食糜迅速而有效地推进。本研究结果提示，在拜特引起的腹泻中，螺旋感染时，阶段性收缩可能会减少运输，因此，允许更多的接触时间吸收水和营养物质。然而，这种反应可能会被巨大的迁移性收缩所抵消，这种收缩会迅速将食糜推进结肠，并加剧与T相关的腹泻。螺旋感染
The effect ofTrichinella spiralisinfection on small intestinal transit and motor activity in the fed state during the intestinal phase of infection was studied. Contractions were recorded by strain gauge transducers, and mean transit time was measured by marker dilution technique. The mean amplitude and area of individual phasic contractions decreased, but no change occurred in their mean duration during trichinosis. The total amplitude and area of phasic contractions also decreased; this was caused by a decrease in the frequency of contractions as well as a decrease in the mean parameters. The reduction in the total duration was entirely caused by the decrease in frequency. The reduction in the total parameters of all contractions was the result of a reduction in the same parameters for both propagating and nonpropagating contractions. However, the decrease in the parameters of propagating contractions was much greater. Also, there was a decrease in the distance of propagation of phasic contractions. The transit time as a result of phasic contractions increased duringT. spiralisinfection. Additionally,T. spiralisinfection induced giant migrating contractions in the fed state that were never observed during control. Chyme was propelled very rapidly and effectively by giant migrating contractions. The findings of the present study suggest that during diarrhea induced byT. spiralisinfection, the phasic contractions may act to decrease transit and, hence, allow more contact time for absorption of water and nutrients. However, this response may be counter-balanced by giant migrating contractions that rapidly propel chyme into the colon and compound the diarrhea associated withT. spiralisinfection.