Association of Genetic Ancestry With DNA Methylation Changes in Prostate Cancer Disparity
Association of Genetic Ancestry With DNA Methylation Changes in Prostate Cancer Disparity
复制标题
DOI：
10.21873/anticanres.13790
复制
发表时间：
2019-11-01
影响因子：
2
通讯作者：
Kwabi-Addo, Bernard
中科院分区：
文献类型：
--
作者：
Apprey, Victor;Wang, Songping;Kwabi-Addo, Bernard
背景：我们假设祖先介导的甲基化DNA变化可能导致前列腺癌（PCa）的种族和民族差异。为了验证这一假设，我们分析了遗传祖先及其与PCa差异中DNA甲基化变化的关系。材料和方法：分别采用焦磷酸测序和祖先信息标记进行DNA甲基化和遗传祖先检测。结果：经Spearman秩相关检验，数据有显著性差异(p
Background: We hypothesized that ancestry-mediated methylated DNA changes may drive racial and ethnic disparity in prostate cancer (PCa). To test this hypothesis, we analyzed genetic ancestry and association with DNA methylation changes in PCa disparity. Materials and Methods: Pyrosequencing and ancestry informative markers were used for DNA methylation and genetic ancestry testing, respectively. Results: Using Spearman rho rank correlation test, the data demonstrated significant (p