Ductal carcinoma in situ of the breast: morphological and molecular features implicated in progression.
Ductal carcinoma in situ of the breast: morphological and molecular features implicated in progression.
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DOI：
10.1042/bsr20130077
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发表时间：
2014-02-01
影响因子：
4
通讯作者：
Andrade VP
中科院分区：
文献类型：
--
作者：
Carraro DM;Elias EV;Andrade VP
乳房X线摄影筛查方案在世界各地的推广，包括在发展中国家的推广，极大地促进了小的不可触及病变的诊断，从而提高了导管原位癌（DCIS）的检出率。DCIS在几个方面是异质性的，例如其临床表现、形态学和基因组谱。据报告，取得了很好的成果;然而，许多问题仍未得到解答。例如，哪些患者群体被过度治疗，而可以从最小的干预中受益，哪些患者群体需要更传统的多学科方法。为了回答这些问题，有必要对DCIS的放射学、形态学和遗传学方面进行全面的综合分析。本文综述了DCIS的形态学和分子生物学特征及其进展，有助于揭示这种疾病的生物学和遗传异质性。近年来获得的知识可能会允许在未来为DCIS女性制定量身定制的临床管理。
The spread of mammographic screening programmes around the world, including in developing countries, has substantially contributed to the diagnosis of small non-palpable lesions, which has increased the detection rate of DCIS (ductal carcinoma in situ). DCIS is heterogeneous in several ways, such as its clinical presentation, morphology and genomic profile. Excellent outcomes have been reported; however, many questions remain unanswered. For example, which patients groups are overtreated and could instead benefit from minimal intervention and which patient groups require a more traditional multidisciplinary approach. The development of a comprehensive integrated analysis that includes the radiological, morphological and genetic aspects of DCIS is necessary to answer these questions. This review focuses on discussing the significant findings about the morphological and molecular features of DCIS and its progression that have helped to uncover the biological and genetic heterogeneity of this disease. The knowledge gained in recent years might allow the development of tailored clinical management for women with DCIS in the future.