Bacterial growth rate reflects a bottleneck in resource allocation
Bacterial growth rate reflects a bottleneck in resource allocation
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DOI：
10.1016/j.bbagen.2011.05.014
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发表时间：
2011-10-01
影响因子：
3
通讯作者：
Fromion, V.
中科院分区：
文献类型：
--
作者：
Goelzer, A.;Fromion, V.
背景：快速生长细菌的生长速率管理目前是一个活跃的研究领域。尽管我们对控制生长速率的分子机制的理解取得了巨大进展，但关于其内在局限性的基本问题今天仍然相关。在平行，系统生物学声称，数学模型可以揭示这些问题。方法：本审查探讨了一些可能的原因，限制在快速增长的细菌的生长速度，使用基于约束的建模方法的系统生物学方法。结果：最近的实验结果和一种新的基于约束的建模方法命名为资源平衡分析（RBA）揭示了细菌细胞中生物过程之间资源分配的限制。在这种情况下，有限数量的资源在代谢网络和核糖体之间的分布限制了生长速率，这意味着这两个过程之间存在瓶颈。任何节约资源的机制都会提高生长速度。一般意义：因此，代谢途径的遗传调控（例如分解代谢产物抑制）的出现，可以作为一种最小化蛋白质成本的手段，即在最小化资源分配的同时最大化生长性能。这篇文章是题为微生物系统生物学的特刊的一部分。(C)2011 Elsevier B.V.保留所有权利。
Background: Growth rate management in fast-growing bacteria is currently an active research area. In spite of the huge progress made in our understanding of the molecular mechanisms controlling the growth rate, fundamental questions concerning its intrinsic limitations are still relevant today. In parallel, systems biology claims that mathematical models could shed light on these questions.Methods: This review explores some possible reasons for the limitation of the growth rate in fast-growing bacteria, using a systems biology approach based on constraint-based modeling methods.Results: Recent experimental results and a new constraint-based modelling method named Resource Balance Analysis (RBA) reveal the existence of constraints on resource allocation between biological processes in bacterial cells. In this context, the distribution of a finite amount of resources between the metabolic network and the ribosomes limits the growth rate, which implies the existence of a bottleneck between these two processes. Any mechanism for saving resources increases the growth rate.General Significance: Consequently, the emergence of genetic regulation of metabolic pathways, e.g. catabolite repression, could then arise as a means to minimise the protein cost, i.e. maximising growth performance while minimising the resource allocation. This article is part of a Special Issue entitled Systems Biology of Microorganisms. (C) 2011 Elsevier B.V. All rights reserved.