Imaging {Au0-PAMAM} gold-dendrimer nanocomposites in cells
Imaging {Au0-PAMAM} gold-dendrimer nanocomposites in cells
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DOI：
10.1023/a:1021692006589
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发表时间：
2002-10-01
影响因子：
2.5
通讯作者：
Balogh, L
中科院分区：
文献类型：
--
作者：
Bielinska, A;Eichman, JD;Balogh, L
树枝状聚合物纳米复合材料（DNC）是由客体原子或小团簇分散和固定在树枝状聚合物基体中形成的杂化纳米粒子。由于其可控的组成、预定的尺寸、形状和可变的表面功能，它们在生物医学应用中具有巨大的潜力。在这项工作中，d = 5-25 nm的球形纳米粒子组成的金和聚（酰胺胺）（PAMAM）树枝状聚合物已被选择来证明这种纳米粒子为基础的概念。合成了具有良好尺寸的{Au（0）（n）-PAMAM}金树枝状聚合物纳米复合物，并通过透射电子显微镜在体外和体内成像。通过利用生物活性客体或通过掺入放射性同位素（例如Au-198），DNC也具有用于成像和药物递送载体的潜力。
Dendrimer nanocomposites (DNC) are hybrid nanoparticles formed by the dispersion and immobilization of guest atoms or small clusters in dendritic polymer matrices. They have a great potential in biomedical applications due to their controlled composition, predetermined size, shape and variable surface functionalities. In this work, d = 5-25 nm spherical nanoparticles composed of gold and poly( amidoamine) ( PAMAM) dendrimers have been selected to demonstrate this nanoparticle based concept. {Au(0)(n)-PAMAM} gold dendrimer nanocomposites with a well-defined size were synthesized and imaged by transmission electron microscopy both in vitro and in vivo. DNC have also the potential to be used for imaging and drug delivery vehicles either by utilizing bioactive guests or through the incorporation of radioactive isotopes, such as Au-198.