International standardization and classification of human papillomavirus types
International standardization and classification of human papillomavirus types
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DOI：
10.1016/j.virol.2014.12.028
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发表时间：
2015-02-01
期刊：
影响因子：
3.7
通讯作者：
Dillner, Joakim
中科院分区：
文献类型：
--
作者：
Bzhalava, Davit;Eklund, Carina;Dillner, Joakim
已建立的人乳头瘤病毒（HPV）分型，最高可达HPV202，属于5属49种。国际HPV参考中心确保HPV类型指定和检测的分类和质量标准的国际标准化。该中心i）接收潜在新型HPV类型的克隆，对其进行重新克隆和重新测序。如果确认，HPV类型编号被分配并张贴在www. hpvcenter.se. ii）根据与发起人商定的材料转让协议，分发参考克隆样本，用于学术研究。iii）提供新序列是否代表新类型的初步检查iv）发布HPV基因分型的国际熟练小组。HPV类型发现率正在增加，可能是因为宏基因组测序。今天，γ属包含79种HPV类型和27种，分别超过了65种和51种HPV类型的β属。定期发布基于HPV参考克隆的熟练度面板，导致全球HPV基因分型服务的改善。(C)2014爱思唯尔公司All rights reserved.
Established Human Papillomavirus (HPV) types, up to HPV202, belong to 49 species in five genera. International standardization in classification and quality standards for HPV type designation and detection is ensured by the International HPV Reference Center. The center i) receives clones of potentially novel HPV types, re-clones and re-sequences them. If confirmed, an HPV type number is assigned and posted on www. hpvcenter.se. ii) distributes reference clone samples, for academic research, under Material Transfer Agreements agreed with the originator. iii) provides preliminary checking of whether new sequences represent novel types iv) issues international proficiency panels for HPV genotyping.The rate of HPV type discovery is increasing, probably because of metagenomic sequencing. gamma-genus today contains 79 HPV types and 27 species, surpassing proportional to and beta genera with 65 and 51 HPV types, respectively. Regular issuing of proficiency panels based on HPV reference clones has resulted in global improvement of HPV genotyping services. (C) 2014 Elsevier Inc. All rights reserved.