Right Frontoinsular Cortex and Subcortical Activity to Infant Cry Is Associated with Maternal Mental State Talk
Right Frontoinsular Cortex and Subcortical Activity to Infant Cry Is Associated with Maternal Mental State Talk
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DOI：
10.1523/jneurosci.1286-15.2015
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发表时间：
2015-09-16
影响因子：
5.3
通讯作者：
Moses-Kolko, Eydie L.
中科院分区：
文献类型：
--
作者：
Hipwell, Alison E.;Guo, Chaohui;Moses-Kolko, Eydie L.
研究的目的是研究人类看护的一个特定组成部分的神经相关性：母亲的精神状态谈话，反映了母亲倾向于将精神状态和意向性归因于婴儿。在功能磁共振成像（fMRI）中，我们使用了一个强有力的、生态相关的婴儿哭声刺激，测试了产后对“自己”和标准“其他”婴儿哭声的神经反应，即右侧额岛皮层（RFIC）和皮质下边缘网络与母亲精神状态谈话的独立观察有关的假设。样本包括76位生活在城市、社会经济地位较低的母亲（82%是非裔美国人）和她们4个月大的婴儿。在fMRI扫描之前，母亲与婴儿面对面的互动被拍摄下来，母亲的行为被训练有素的研究人员编码，他们不知道参与者的所有其他信息。结果显示，与其他婴儿哭声相比，在组水平上，RFIC的功能活动更高。此外，RFIC和双侧皮质下神经活动（如丘脑、杏仁核、海马体、壳核）与母亲的精神状态谈话呈正相关，但与观察到的照顾的更全面方面无关。这些发现在考虑到感知和上下文协变量时成立，例如母亲感到痛苦，迫切需要帮助，抑郁严重程度和对自己婴儿哭声的认识。我们的研究结果强调需要关注照顾的具体组成部分，以促进对母亲大脑的理解。未来的工作将研究这种神经标记对母子功能的预测效用。
The study objective was to examine neural correlates of a specific component of human caregiving: maternal mental state talk, reflecting a mother's proclivity to attribute mental states and intentionality to her infant. Using a potent, ecologically relevant stimulus of infant cry during fMRI, we tested hypotheses that postpartum neural response to the cry of "own" versus a standard "other" infant in the right frontoinsular cortex (RFIC) and subcortical limbic network would be associated with independent observations of maternal mental state talk. The sample comprised 76 urban-living, low socioeconomic mothers (82% African American) and their 4-month-old infants. Before the fMRI scan, mothers were filmed in face-to-face interaction with their infant, and maternal behaviors were coded by trained researchers unaware of all other information about the participants. The results showed higher functional activity in the RFIC to own versus other infant cry at the group level. In addition, RFIC and bilateral subcortical neural activity (e.g., thalamus, amygdala, hippocampus, putamen) was associated positively with maternal mental state talk but not with more global aspects of observed caregiving. These findings held when accounting for perceptual and contextual covariates, such as maternal felt distress, urge to help, depression severity, and recognition of own infant cry. Our results highlight the need to focus on specific components of caregiving to advance understanding of the maternal brain. Future work will examine the predictive utility of this neural marker for mother-child function.