PULSATILE SECRETION OF LH, FSH, PROLACTIN, ESTRADIOL AND PROGESTERONE DURING THE HUMAN MENSTRUAL-CYCLE
PULSATILE SECRETION OF LH, FSH, PROLACTIN, ESTRADIOL AND PROGESTERONE DURING THE HUMAN MENSTRUAL-CYCLE
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DOI：
10.1111/j.1365-2265.1982.tb02631.x
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发表时间：
1982-01-01
影响因子：
3.2
通讯作者：
BAIRD, DT
中科院分区：
文献类型：
--
作者：
BACKSTROM, CT;MCNEILLY, AS;BAIRD, DT
本文研究了正常妇女月经周期不同阶段促性腺激素和卵巢类固醇的脉冲性分泌。每隔15分钟采集一次血浆样本，持续6小时，测定LH（促黄体生成素）、FSH、催乳素（PRL）、雌二醇和孕酮的浓度，并估计激素的每次发作脉冲的频率和振幅。虽然每种激素的浓度都有显著的波动，但LH显示出最容易识别的脉冲，其频率从周期的早期卵泡期到晚期卵泡期显著增加（3.4 ± 0.01）。0.3 vs. 4.4 .+-。0.2每6小时脉冲数P < 0.01）。在黄体期，LH的基础浓度（5.6 ± 0.01）。0.9 U/l）、脉冲幅度（7.4 . ±. 1.7 U/l）和频率（1.6 . ±. 0.2每6 h）明显低于卵泡期各期（P < 0.001）。FSH和PRL的浓度在整个月经周期中表现出与LH相似但不太显著的变化，在周期的黄体期，基础浓度和脉冲频率均显著下降。虽然只有47%的LH脉冲与FSH脉冲相关，但70%的FSH和PL脉冲发生在LH脉冲的15分钟内。从卵泡早期到卵泡晚期，基础雌二醇浓度显著升高（P < 0.001）。有证据表明雌二醇的间歇性分泌，脉冲频率从最大值4.3 ± 1.5下降。0.6在卵泡中期每6小时增加至1.8 ± 0.5。0.5黄体期每6 h增加1次（P < 0.02）。在卵泡期，74-80%的LH脉冲后100分钟内雌二醇浓度显着上升。LH、FSH、PRL、雌二醇和孕酮的分泌本质上是偶发性的; FSH、LH和PRL的大量分泌事件是巧合的;排卵前卵泡的雌二醇分泌增加与LH偶发性脉冲频率的升高相关。
The pulsatile secretion of gonadotropins and ovarian steroids was studied in normal women at different stages of the menstrual cycle. The concentrations of LH [luteinizing hormone], FSH, prolactin (PRL), estradiol and progesterone were measured in samples of plasma collected every 15 min for 6 h, and the frequency and amplitude of each episodic pulse of hormone estimated. Although significant fluctuations occurred in the concentration of each hormone, LH showed the most easily identifiable pulses the frequency of which increased significantly from the early follicular to the late follicular phase of the cycle (3.4 .+-. 0.3 vs. 4.4 .+-. 0.2 pulses per 6 h P < 0.01). During the luteal phase the basal concentration of LH (5.6 .+-. 0.9 U/l), pulse amplitude (7.4 .+-. 1.7 U/l) and frequency (1.6 .+-. 0.2 per 6 h) were much lower than at any stage of the follicular phase (P < 0.001). The concentration of FSH and PRL showed a similar but less marked change to that of LH throughout the menstrual cycle with a significant decline in both basal concentration and pulse frequency in the luteal phase of the cycle. Although only 47% of all LH pulses were associated with a pulse of FSH, 70% of FSH and PL pulses occurred within 15 min of an LH pulse. The basal concentration of estradiol increased significantly from the early follicular to the late follicular phase of the cycle (P < 0.001). There was evidence of episodic secretion of estradiol with the frequency of pulses declining from a maximum of 4.3 .+-. 0.6 per 6 h in the mid-follicular phase to 1.8 .+-. 0.5 per 6 h in the luteal phase (P < 0.02). In the follicular phase 74-80% of LH pulses were followed within 100 min by a significant rise in the concentration of estradiol. The secretion of LH, FSH, PRL, estradiol and progesterone is episodic in nature; a significant number of secretory episodes of FSH, LH and PRL are coincidental; and the increased secretion of estradiol from the pre-ovulatory follicle is associated with a rise in the frequency of episodic pulses of LH.