The blood-brain barrier: structure, regulation, and drug delivery.
The blood-brain barrier: structure, regulation, and drug delivery.
复制标题
血脑屏障：结构、调节和药物输送。
DOI：
10.1038/s41392-023-01481-w
复制
发表时间：
2023-05-25
影响因子：
39.3
通讯作者：
Wang, Yi
中科院分区：
文献类型：
--
作者：
Wu, Di;Chen, Qi;Chen, Xiaojie;Han, Feng;Chen, Zhong;Wang, Yi
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates the pharmacotherapy for CNS disorders as the most chemical drugs and biopharmaceuticals have been impeded to enter the brain. Insufficient drug delivery into the brain leads to low therapeutic efficacy as well as aggravated side effects due to the accumulation in other organs and tissues. Recent breakthrough in materials science and nanotechnology provides a library of advanced materials with customized structure and property serving as a powerful toolkit for targeted drug delivery. In-depth research in the field of anatomical and pathological study on brain and BBB further facilitates the development of brain-targeted strategies for enhanced BBB crossing. In this review, the physiological structure and different cells contributing to this barrier are summarized. Various emerging strategies for permeability regulation and BBB crossing including passive transcytosis, intranasal administration, ligands conjugation, membrane coating, stimuli-triggered BBB disruption, and other strategies to overcome BBB obstacle are highlighted. Versatile drug delivery systems ranging from organic, inorganic, and biologics-derived materials with their synthesis procedures and unique physio-chemical properties are summarized and analyzed. This review aims to provide an up-to-date and comprehensive guideline for researchers in diverse fields, offering perspectives on further development of brain-targeted drug delivery system.
登录
查看更多内容
影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
通讯作者：
Wood, Matthew J. A.
影响因子：
12.4
作者：
Al-Ahmady, Zahraa S.;Dickie, Ben R.;Aldred, Isabelle;Jasim, Dhifaf A.;Barrington, Jack;Haley, Michael;Lemarchand, Eloise;Coutts, Graham;Kaur, Satinderdeep;Bates, Jessica;Curran, Sarah;Goddard, Ruth;Walker, Megan;Parry-jones, Adrian;Kostarelos, Kostas;Allan, Stuart M.
通讯作者：
Allan, Stuart M.
影响因子：
3.5
作者：
Araya, Runa;Kudo, Moeko;Yamada, Masahisa
通讯作者：
Yamada, Masahisa
影响因子：
7.2
作者：
Anderson, James M.;Van Itallie, Christina M.
通讯作者：
Van Itallie, Christina M.
影响因子：
64.8
作者：
Armulik, Annika;Genove, Guillem;Betsholtz, Christer
通讯作者：
Betsholtz, Christer