Relationships among msx gene structure and function in zebrafish and other vertebrates
Relationships among msx gene structure and function in zebrafish and other vertebrates
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DOI：
10.1093/oxfordjournals.molbev.a025707
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发表时间：
1997-10-01
影响因子：
10.7
通讯作者：
Westerfield, M
中科院分区：
文献类型：
--
作者：
Ekker, M;Akimenko, MA;Westerfield, M
斑马鱼基因组中至少含有5个msx同源盒基因：msxA、msxB、msxC、msxD和新分离的msxE。虽然这些基因共享的结构特征共同的所有Msx基因，蛋白质序列的系统发育分析表明，从斑马鱼的msx基因不是orthopathic到哺乳动物，鸟类和两栖动物的Msx1和Msx2基因。斑马鱼msxB和msxC彼此之间以及与小鼠Msx3的关系更密切。同样，虽然斑马鱼msx基因在胚胎背神经外胚层，内脏弓，鳍，和感觉器官的组合表达表明与其他脊椎动物的Msx基因的功能相似，表达模式的差异排除了精确的分配的直系关系。不同的重复事件可能导致了现代鱼类和其他脊椎动物谱系的msx基因，而msx基因在胚胎发育过程中的许多功能都被保留了下来。
The zebrafish genome contains at least five msx homeobox genes, msxA, msxB, msxC, msxD, and the newly isolated msxE. Although these genes share structural features common to all Msx genes, phylogenetic analyses of protein sequences indicate that the msx genes from zebrafish are not orthologous to the Msx1 and Msx2 genes of mammals, birds, and amphibians. The zebrafish msxB and msxC are more closely related to each other and to the mouse Msx3. Similarly, although the combinatorial expression of the zebrafish msx genes in the embryonic dorsal neuroectoderm, visceral arches, fins, and sensory organs suggests functional similarities with the Msx genes of other vertebrates, differences in the expression patterns preclude precise assignment of orthological relationships. Distinct duplication events may have given rise to the msx genes of modern fish and other vertebrate lineages whereas many aspects of msx gene functions during embryonic development have been preserved.